Coordinator and PI, The Himalayan Centre for High-throughput Computational Biology (HiCHiCoB), A BIC, supported by DBT, Govt. of India
PI, Scientist and Group Leader
Coordinator, Bioinformatics Programme, AcSIR@CSIR-IHBT
Studio of Computational Biology & Bioinformatics
Division of Biotechnology,
CSIR-Institute of Himalyan Bioresources Technology
Palampur(Himachal Pradesh), India.
Email: ravishihbt.res.in; ravish9gmail.com
Schooling: Kendriya Vidyalaya, Kankerbaugh, Patna, 1994
B.Sc from University of Delhi, 1997
M.Sc Biochemistry, Jamia Hamdard, New Delhi, 1999
Post Graduate Advanced Diploma in Bioinformatics, JNU, New Delhi 2001
Ph.D Bioinformatics/Biotechnology, IGIB, CSIR, Delhi, 2006.
Professional and Research Experience
Researcher at Genetic Information Research Institute (GIRI), Mountain View, California, USA, 2007.
Main Bioinformatician, BIOBASE International (Transfac fame), Bangalore, 2008.
Faculty in Bioinformatics, Indian Institute of Advanced Research, Gandhinagar, Gujarat, 2009.
Total Ph.Ds guided towards completion: 8
Dr. Ashwani Jha
Dr. Mrigaya Mehra
Dr. Vandana Chawla
Dr. Indu Gangwar
Dr. Ganesh Panzade
Dr. Ajay Kumar
Dr. Nitesh Kumar Sharma
Mr. Upendra Kumar Pradhan
Fellowships and Recognition
NIH, USA project fellow
DST/SERB Young Scientist Fast Track Grant Award.
Member, Board of Examiners, Central University of Bihar.
INSA-Australian Academy of Science Visiting Scientist Fellowship, 2012-13.
Visiting faculty and CDC committee member, Central University of Himachal Pradesh.
UGC ENCORE Faculty for University of Jammu.
Talks and Poster Presentations Delivered
"MiRNA: The "Little Master" of Gene Regulation", Indian Institute of Technology (IIT), Mandi. April 8, 2011.
"A MicroRNA target refinement method and tool", Indian Institute of Integrative Medicine, Jammu, June 26, 2009.
"AF-1: Finding Alus in Primate Genomes", Lecture Delivered at Faculty of Technology and Applied Mathematics, MS University, Baroda, Gujarat, 2008.
"Alu repeats as a caravan to regulatory house". Poster presented at BioTech 2004,India International Center, N. Delhi, 2004.
"Alu repeats as a caravan to regulatory house", A presentation during Celebration of 50 years of Triple Helix. Vigyan Bhawan, New Delhi. 2004. (Presentation given before Honorable President of India, Dr. APJ Kalam.)
"Strategies in Regulatory Elements Finding" at CeBiTech. The Bioinformatics Graduate School, Bielefeld, Germany. Research work presented on invitation from Beilefeld University, Germany (2003).
"Motif Finding and Statistics." at Informatics N. Delhi-2002.
"The HMM." at Informatics, N. Delhi-2002.
Academic Referee/Reviewer for Journals/Publishers
Nucleic Acids Research
RNA (Cold Spring Harbor Lab Publication)
Nature Scientific Reports
Genomics, Proteomics and Bioinformatics
Plant Molecular Biology
Journal of Biosciences
Journal of Genetics
Refree for National and International Grant Funding Agencies
Reviewer for Department of Science & Technology (DST), Government of India.
Course Director and Organizer
National Bioinformatics Workshop on "The Bioinformatics of Next Generation Sequencing" June 17-18, 2010, IHBT, CSIR, Palampur. (~~The first DBT, Government of India Sponsored Workshop on NGS in India~~)
Funded Project Grants Attracted:
Project titled "The Himalayan Centre for High-throughput Computational Biology (HiCHiCoB)", sanctioned for funding by the DBT, Government of India.
Project titled "iPRESS: Integrated Plant REgulomics Software & Server", sanctioned for funding by the CSIR, India.
Project titled " Exploration of RBP-RNA interactions to reveal the post-transcriptional regulatory impact and development of related tools and resource server", sanctioned for funding by the Department of Biotechnology.
Project titled "Epigenetic and transcriptional regulation by small RNAs: a computational approach", sanctioned for funding by the Department of Science and Technology.
Project titled "Identification of De novo non-coding transcripts in Human Brain [HUNT]", Project Funded under "Encouraging and Motivating Pursuit of World Class Exploratory Research " [EMPOWER] CSIR, India.
Project titled "Regulatory system Analysis with respect to microRNAs and development of related softwares and Servers", sanctioned for funding by DBT.
Project titled "Understanding plant-nematode interaction: Identification of plant and nematode genes involved in disease development", sanctioned for funding by Indian Council of Agricultural Research (ICAR).
Project titled "Profiling and characterization of early phase differential mi-RNA(s) responsible for downstream development of insulin resistance in hMSC derived adipocytes", sanctioned for funding by DBT.
National 12th Five Year Plan Project for Computational Biology, "GENESIS" (2012-2017).
National 12th Five Year Plan Project for Epigenetics, "EpiHED" (2012-2017).
* Besides these projects, Co-PI in several other projects, funded by DBT and CSIR.
Selected Publications: (Full updated list available at Google Scholar link: Updated Publication )
miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin. Journal of Endocrinology, 2 July 2018 Read accepted preprint research article here Sujith Rajan, Ganesh Panzade, Ankita Srivastava, Kripa Shankar, Rajesh Pandey, Abhishek Gupta, Durgesh Kumar, Salil Varshney, Muheeb beg, Raj Kumar Mishra, Ravi Shankar* and Anil Gaikwad*.
Transcriptome and Co-Expression Network Analyses Identify Key Genes Regulating Nitrogen Use Efficiency in Brassica juncea L. Scientific Reports, 2018;doi:10.1038/s41598-018-25826-6 Read research article here Parul Goel†, Nitesh Kumar Sharma†, Monika Bhuria, Vishal Sharma, Rohit Chauhan, Shivalika Pathania, Mohit Kumar Swarnkar, Vandna Chawla, Vishal Acharya, Ravi Shankar* and Anil Kumar Singh*.
Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis Scientific Reports, 2017;doi:10.1038/s41598-017-01765-6 Read research article here Indu Gangwar†, Nitesh Kumar Sharma†, Ganesh Panzade, Supriya Awasthi, Anurag Agrawal and Ravi Shankar*.
Comparative Transcriptome Analysis of Chinary, Assamica and Cambod tea (Camellia sinensis) Types during Development and Seasonal Variation using RNA-seq Technology. Scientific Reports, 2016 Ajay Kumar†, Vandna Chawla†, Eshita Sharma, Pallavi Mahajan, Ravi Shankar* and Sudesh Yadav*.
Genome-wide regulatory dynamics of G-Quadruplexes in human malaria parasite Plasmodium falciparum. Genomics, Oct 2016 Deeksha Bhartiya†, Vandna Chawla†, Sourav Ghosh, Ravi Shankar, Niti Kumar
Transcriptome Analysis Reveals Candidate Genes involved in Blister Blight defense in Tea (Camellia sinensis (L) Kuntze). Scientific Reports, Jul 2016 Kuldip Jayaswall, Pallavi Mahajan, Gagandeep Singh, Rajni Parmar, Romit Seth, Aparnashree Raina , Mohit k Swarnkar, Anil Singh, Ravi Shankar, Ram K Sharma.
Identifying wrong assemblies in de novo short read primary sequence assembly contigs. Journal Of Biosciences, September 2016 Vandna Chawla, Rajnish Kumar and Ravi Shankar*.
Global de novo protein-protein interactome elucidates interactions of drought responsive proteins in horsegram (Macrotyloma uniflorum). Journal of proteome research; May 10, 2016 Bhardwaj Jyoti†, Gangwar Indu†, Panzade Ganesh, Ravi Shankar*, Kumar Sudesh*.
Transcriptome analysis of stem wood of Nothapodytes nimmoniana (Graham) Mabb. identifies genes associated with biosynthesis of camptothecin, an anti-carcinogenic molecule. J Bioscience, Mar 2016 Manjunath BL, Singh HR, Ravikanth G, Karaba NN, Shankar R, Kumar S, Uma Shankeer R
A legion of potential regulatory sRNAs exists beyond the typical microRNAs microcosm. (Nucleic Acids Research[NAR]), 2015 Ashwani Jha, Ganesh Panzade, Rajesh Pandey and Ravi Shankar*.
Global de novo protein-protein interactome elucidates interactions of drought responsive proteins in horsegram (Macrotyloma uniflorum). Bhardwaj Jyoti†, Gangwar Indu†, Panzade Ganesh, Shankar Ravi*, Kumar Sudesh*. Journal of proteome research; May 10, 2016
A Deluge of Complex Repeats: The Solanum Genome. (Accepted at PLOS ONE)Mrigaya Mehra, Indu Gangwar, Ravi Shankar*.
Expression of SOD and APX genes positively regulates secondary cell wall biosynthesis and promotes plant growth and yield in Arabidopsis under salt stress.
Amrina Shafi, Rohit Chauhan, Tejpal Gill, Mohit K. Swarnkar, Yelam Sreenivasulu, Sanjay Kumar, Neeraj Kumar, Ravi Shankar, Paramvir Singh Ahuja, Anil Kumar Singh
Plant Mol. Biol., April 2015, Volume 87, Issue 6, pp 615-631
RNA-seq-mediated transcriptome analysis of actively growing and winter dormant shoots identifies non-deciduous habit of evergreen tree tea during winters.
Asosii Paul†, Ashwani Jha†, Shruti Bhardwaj, Sewa Singh, Ravi Shankar*, Sanjay Kumar*. Sci. Rep., 2014. doi:10.1038/srep05932
miRNAting control of DNA methylation. Ashwani Jha and Ravi Shankar*.J biosci. 39 365-380.
Comprehensive Transcriptomic Study on horse gram (Macrotyloma uniflorum): De novo Assembly, Functional Characterization and Comparative Analysis in Relation to Drought Stress. Jyoti Bhardwaj†, Rohit Chauhan†, Mohit Swarnkar, R Chahota, R Shankar* and S Yadav*.BMC Genomics. 2013 14:647, September 2013.
Transcriptome sequencing of rhizome tissue of Sinopodophyllum hexandrum at two temperatures.
A Kumari†, HR Singh†, A Jha, MK Swarnkar, R Shankar*, S Kumar*.
BMC Genomics, 15 (1), 871.
miReader: Discovering novel miRNAs in species without sequenced genome. Ashwani Jha† and Ravi Shankar*† PLoS ONE 8(6): e66857. doi:10.1371/journal.pone.0066857
De-novo sequence assembly and transcriptome analysis of Venturia inaequalis, the deadly apple scab pathogen. Karnika Thakur†,Vandna Chawla†, Shammi Bhatti, Mohit Kumar Swarnkar, Jagdeep Kaur, Ravi Shankar*, Gopaljee Jha*. PLoS ONE 8(1): e53937. doi:10.1371/journal.pone.0053937.
miR-BAG: Bagging Based Identification of MicroRNA Precursors. Ashwani Jha†, Rohit Chauhan†, Mrigaya Mehra†, Heikham Russiachand Singh, Ravi Shankar* PLOS ONE 2012 7(9): e45782. doi:10.1371/journal.pone.0045782.
De novo sequencing and characterization of Picrorhiza kurrooa transcriptome at two temperatures showed major transcriptome adjustments. Parul Gahlan†, Heikham Russiachand Singh†, Ravi Shankar1*, Niharika Sharma, Anita Kumari, Vandna Chawla, Paramvir Singh Ahuja, Sanjay Kumar2*. BMC Genomics, 13:126, March, 2012.
Employing machine learning for reliable miRNA target identificaiton in plants. Ashwani Jha and Ravi Shankar*. BMC Genomics,12:636, December, 2011.
The Regulatory Epicenter of microRNAs. Ashwani Jha, Mrigaya Mehra, Ravi Shankar*. J Biosci. 2011 Sep;36(4):621-38.
EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Aggarwal et al. PNAS, 107, 44, 2010
"The Bioinformatics of Next Generation Sequencing": A meeting report. Journal of Mol. Cell Biol. (Oxford University Press) 2010. Ravi Shankar*.
Flanking region sequence information to improve microRNA target prediction. Journal of Biosciences, Springer, 35(1), March 2010, 105-118 Russiachand Heikham and Ravi Shankar*.
Involvement of repeats in non-random genomic divergence in 5' upstream regions of Human and Chimpanzee genes of different biological processes. HUGO's 13th international meeting on the Human Genome. The HUGO Journal (Genomic Medicine) (2008) 2:401-413. Chaurasia A, Shankar R, Mukerji M
Non-random genomic divergence in repetitive sequences of human and chimpanzee in genes of different functional categories. Mol Genet Genomics.2007 Apr;277(4):441-55. Shankar R, Chaurasia A, Ghosh B, Chekmenev D, Cheremushkin E, Kel A, Mukerji M
Evolution and distribution of RNA polymerase II regulatory sites from RNA polymerase III dependant mobile Alu elements. BMC Evolutionary Biology, BMC Evol Biol. 2004 Oct 4;4(1):37 Shankar R, Grover D, Brahmachari S K, Mukerji M.
Repbase Reports. 2006, Vol. 6, Issue 10. Shankar R & Jerzy Jurka.
Developed by Heikham Russiachand Singh (past member) and Maintained by SCBB, Biotech Division.