GO description GO terms Number of srRNAs
Seed Number of miRNAs Number of Genes
DNA helicase activity
GO:0003678
1282
AT DNA binding
GO:0003680
770
Bent DNA binding
GO:0003681
8
Chromatin binding
GO:0003682
5914
Damaged DNA binding
GO:0003684
4019
DNA replication origin binding
GO:0003688
7
DNA clamp loader activity
GO:0003689
961
Double-stranded DNA binding
GO:0003690
2815
Double-stranded telomeric DNA binding
GO:0003691
1295
Left-handed Z-DNA binding
GO:0003692
619
Satellite DNA binding
GO:0003696
125
Single-stranded DNA binding
GO:0003697
3815
Sequence-specific DNA binding transcription factor activity
GO:0003700
7663
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003705
1669
Steroid hormone receptor activity
GO:0003707
3114
Retinoic acid receptor activity
GO:0003708
67
Transcription cofactor activity
GO:0003712
3781
Transcription coactivator activity
GO:0003713
5261
Transcription corepressor activity
GO:0003714
5029
Telomerase activity
GO:0003720
1190
RNA binding
GO:0003723
6478
RNA helicase activity
GO:0003724
604
Double-stranded RNA binding
GO:0003725
2567
Double-stranded RNA adenosine deaminase activity
GO:0003726
1106
Single-stranded RNA binding
GO:0003727
2515
MRNA binding
GO:0003729
3692
MRNA 3'-UTR binding
GO:0003730
670
Structural constituent of ribosome
GO:0003735
4488
Translation initiation factor activity
GO:0003743
3422
Translation elongation factor activity
GO:0003746
1354
Translation release factor activity
GO:0003747
1097
Peptidyl-prolyl cis-trans isomerase activity
GO:0003755
2742
Protein disulfide isomerase activity
GO:0003756
437
Motor activity
GO:0003774
3682
Microtubule motor activity
GO:0003777
3832
Actin binding
GO:0003779
6606
Actin monomer binding
GO:0003785
1525
Lysozyme activity
GO:0003796
886
Protein-glutamine gamma-glutamyltransferase activity
GO:0003810
22
Antigen binding
GO:0003823
2149
Catalytic activity
GO:0003824
5143
Alpha-ketoacid dehydrogenase activity
GO:0003826
2
Alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0003827
5
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0003828
1025
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0003829
360
Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0003830
5
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003831
24
Beta-galactoside alpha-2,6-sialyltransferase activity
GO:0003835
731
Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0003836
379
Gamma-glutamyltransferase activity
GO:0003840
746
1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0003841
1247
1-pyrroline-5-carboxylate dehydrogenase activity
GO:0003842
3
1,4-alpha-glucan branching enzyme activity
GO:0003844
3
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
GO:0003845
1
2-acylglycerol O-acyltransferase activity
GO:0003846
282
1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0003847
1568
2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0003851
44
3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0003854
343
3-hydroxyacyl-CoA dehydrogenase activity
GO:0003857
294
3-hydroxybutyrate dehydrogenase activity
GO:0003858
744
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
GO:0003863
2
3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0003865
4
4-aminobutyrate transaminase activity
GO:0003867
7
4-hydroxyphenylpyruvate dioxygenase activity
GO:0003868
14
5-aminolevulinate synthase activity
GO:0003870
2
6-phosphofructokinase activity
GO:0003872
5
6-phosphofructo-2-kinase activity
GO:0003873
145
6-pyruvoyltetrahydropterin synthase activity
GO:0003874
1
ADP-ribosylarginine hydrolase activity
GO:0003875
7
AMP deaminase activity
GO:0003876
14
ATP citrate synthase activity
GO:0003878
5
Protein C-terminal carboxyl O-methyltransferase activity
GO:0003880
1629
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0003881
4
CTP synthase activity
GO:0003883
7
D-amino-acid oxidase activity
GO:0003884
1
DNA (cytosine-5-)-methyltransferase activity
GO:0003886
546
DNA-directed DNA polymerase activity
GO:0003887
3215
DNA primase activity
GO:0003896
207
DNA-directed RNA polymerase activity
GO:0003899
2932
Deoxyribodipyrimidine photo-lyase activity
GO:0003904
10
DNA-(apurinic or apyrimidinic site) lyase activity
GO:0003906
903
Methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0003908
1
DNA ligase activity
GO:0003909
7
DNA ligase (ATP) activity
GO:0003910
7
DNA nucleotidylexotransferase activity
GO:0003912
1
DNA (6-4) photolyase activity
GO:0003914
10
DNA topoisomerase activity
GO:0003916
5
DNA topoisomerase type I activity
GO:0003917
534
DNA topoisomerase (ATP-hydrolyzing) activity
GO:0003918
9
FMN adenylyltransferase activity
GO:0003919
348
GMP reductase activity
GO:0003920
8
GPI-anchor transamidase activity
GO:0003923
24
GTPase activity
GO:0003924
6076
GTP cyclohydrolase I activity
GO:0003934
2
IMP cyclohydrolase activity
GO:0003937
2
IMP dehydrogenase activity
GO:0003938
5
L-iditol 2-dehydrogenase activity
GO:0003939
2
L-iduronidase activity
GO:0003940
2
L-serine ammonia-lyase activity
GO:0003941
361
N-acetylgalactosamine-4-sulfatase activity
GO:0003943
891
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
GO:0003944
4
N-acetyllactosamine synthase activity
GO:0003945
11
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
GO:0003948
71
NAD+ ADP-ribosyltransferase activity
GO:0003950
1465
NAD+ kinase activity
GO:0003951
2163
NAD+ nucleosidase activity
GO:0003953
62
NADH dehydrogenase activity
GO:0003954
14
NAD(P)H dehydrogenase (quinone) activity
GO:0003955
685
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0003956
4
NAD(P)+ transhydrogenase (B-specific) activity
GO:0003957
5
NADPH-hemoprotein reductase activity
GO:0003958
1503
NADPH:quinone reductase activity
GO:0003960
13
RNA-3'-phosphate cyclase activity
GO:0003963
1078
RNA-directed RNA polymerase activity
GO:0003968
3
(S)-2-hydroxy-acid oxidase activity
GO:0003973
3
UDP-N-acetylglucosamine 4-epimerase activity
GO:0003974
3
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0003975
1
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0003976
455
UDP-N-acetylglucosamine diphosphorylase activity
GO:0003977
2
UDP-glucose 4-epimerase activity
GO:0003978
3
UDP-glucose 6-dehydrogenase activity
GO:0003979
773
UTP:glucose-1-phosphate uridylyltransferase activity
GO:0003983
2
Acetyl-CoA C-acetyltransferase activity
GO:0003985
5
Acetyl-CoA hydrolase activity
GO:0003986
160
Acetate-CoA ligase activity
GO:0003987
8
Acetyl-CoA C-acyltransferase activity
GO:0003988
5
Acetyl-CoA carboxylase activity
GO:0003989
1051
Acetylcholinesterase activity
GO:0003990
7
Acid phosphatase activity
GO:0003993
507
Acyl-CoA dehydrogenase activity
GO:0003995
2572
Acyl-CoA ligase activity
GO:0003996
1
Acyl-CoA oxidase activity
GO:0003997
1601
Adenosine deaminase activity
GO:0004000
1312
Adenosine kinase activity
GO:0004001
2
ATP-dependent DNA helicase activity
GO:0004003
2037
ATP-dependent RNA helicase activity
GO:0004004
763
Copper-exporting ATPase activity
GO:0004008
440
Phospholipid-translocating ATPase activity
GO:0004012
1277
Adenosylhomocysteinase activity
GO:0004013
283
Adenylate cyclase activity
GO:0004016
1003
Adenylate kinase activity
GO:0004017
826
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0004018
2
Adenylosuccinate synthase activity
GO:0004019
1
Adenylylsulfate kinase activity
GO:0004020
9
L-alanine:2-oxoglutarate aminotransferase activity
GO:0004021
2
Alcohol dehydrogenase (NAD) activity
GO:0004022
13
Alcohol dehydrogenase activity, zinc-dependent
GO:0004024
15
Alcohol sulfotransferase activity
GO:0004027
14
3-chloroallyl aldehyde dehydrogenase activity
GO:0004028
817
Aldehyde dehydrogenase (NAD) activity
GO:0004029
3102
Aldehyde dehydrogenase [NAD(P)+] activity
GO:0004030
817
Aldehyde oxidase activity
GO:0004031
10
Alditol:NADP+ 1-oxidoreductase activity
GO:0004032
432
Aldo-keto reductase (NADP) activity
GO:0004033
454
Aldose 1-epimerase activity
GO:0004034
749
Alkaline phosphatase activity
GO:0004035
18
Allantoicase activity
GO:0004037
1
Amidase activity
GO:0004040
2
Acetyl-CoA:L-glutamate N-acetyltransferase activity
GO:0004042
3
L-aminoadipate-semialdehyde dehydrogenase activity
GO:0004043
519
Amidophosphoribosyltransferase activity
GO:0004044
7
Aminoacylase activity
GO:0004046
5
Aminomethyltransferase activity
GO:0004047
1609
Arachidonate 5-lipoxygenase activity
GO:0004051
2
Arachidonate 12-lipoxygenase activity
GO:0004052
194
Arginase activity
GO:0004053
1
Argininosuccinate synthase activity
GO:0004055
2
Argininosuccinate lyase activity
GO:0004056
139
Arginyltransferase activity
GO:0004057
6
Aromatic-L-amino-acid decarboxylase activity
GO:0004058
1
Aralkylamine N-acetyltransferase activity
GO:0004059
118
Arylamine N-acetyltransferase activity
GO:0004060
123
Arylformamidase activity
GO:0004061
713
Aryl sulfotransferase activity
GO:0004062
179
Aryldialkylphosphatase activity
GO:0004063
1
Arylesterase activity
GO:0004064
3
Arylsulfatase activity
GO:0004065
2257
Asparaginase activity
GO:0004067
72
Aspartate 1-decarboxylase activity
GO:0004068
15
L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004069
5
Aspartate carbamoyltransferase activity
GO:0004070
6
Biliverdin reductase activity
GO:0004074
1
Biotin carboxylase activity
GO:0004075
1055
Biotin-[acetyl-CoA-carboxylase] ligase activity
GO:0004077
523
Biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
GO:0004078
523
Biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
GO:0004079
523
Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO:0004080
523
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004081
4
Bisphosphoglycerate mutase activity
GO:0004082
1
Bisphosphoglycerate 2-phosphatase activity
GO:0004083
1
Branched-chain-amino-acid transaminase activity
GO:0004084
13
Butyryl-CoA dehydrogenase activity
GO:0004085
3
Carbamoyl-phosphate synthase (ammonia) activity
GO:0004087
135
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004088
135
Carbonate dehydratase activity
GO:0004089
860
Carbonyl reductase (NADPH) activity
GO:0004090
199
Carnitine O-acetyltransferase activity
GO:0004092
4
Carnitine O-palmitoyltransferase activity
GO:0004095
1832
Catalase activity
GO:0004096
3
Cerebroside-sulfatase activity
GO:0004098
1286
Choline O-acetyltransferase activity
GO:0004102
4
Choline kinase activity
GO:0004103
1
Cholinesterase activity
GO:0004104
8
Choline-phosphate cytidylyltransferase activity
GO:0004105
565
Coproporphyrinogen oxidase activity
GO:0004109
11
Creatine kinase activity
GO:0004111
4
Cyclic-nucleotide phosphodiesterase activity
GO:0004112
1187
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
GO:0004113
152
3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004114
3301
3',5'-cyclic-AMP phosphodiesterase activity
GO:0004115
2461
Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0004117
24
CGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0004118
1193
CGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0004119
26
Cystathionine beta-synthase activity
GO:0004122
2
Cystathionine gamma-lyase activity
GO:0004123
301
Cytidine deaminase activity
GO:0004126
1161
Cytochrome-b5 reductase activity
GO:0004128
1763
Cytochrome-c oxidase activity
GO:0004129
1163
Glycogen debranching enzyme activity
GO:0004133
83
4-alpha-glucanotransferase activity
GO:0004134
83
Amylo-alpha-1,6-glucosidase activity
GO:0004135
83
Deoxycytidine kinase activity
GO:0004137
106
Deoxyribose-phosphate aldolase activity
GO:0004139
1
Dephospho-CoA kinase activity
GO:0004140
5
Diacylglycerol cholinephosphotransferase activity
GO:0004142
6
Diacylglycerol kinase activity
GO:0004143
1507
Diacylglycerol O-acyltransferase activity
GO:0004144
284
Diamine N-acetyltransferase activity
GO:0004145
1
Dihydrofolate reductase activity
GO:0004146
1208
Dihydrolipoyl dehydrogenase activity
GO:0004148
6
Dihydrolipoyllysine-residue succinyltransferase activity
GO:0004149
2
Dihydroorotase activity
GO:0004151
6
Dihydroorotate dehydrogenase activity
GO:0004152
19
6,7-dihydropteridine reductase activity
GO:0004155
2
Dihydropyrimidinase activity
GO:0004157
6
Dimethylallyltranstransferase activity
GO:0004161
750
Diphosphomevalonate decarboxylase activity
GO:0004163
1
Diphthine synthase activity
GO:0004164
4
Dodecenoyl-CoA delta-isomerase activity
GO:0004165
284
Dolichol kinase activity
GO:0004168
2
Dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0004169
3
DUTP diphosphatase activity
GO:0004170
3
Electron-transferring-flavoprotein dehydrogenase activity
GO:0004174
476
Endopeptidase activity
GO:0004175
832
ATP-dependent peptidase activity
GO:0004176
1202
Aminopeptidase activity
GO:0004177
3425
Carboxypeptidase activity
GO:0004180
2051
Metallocarboxypeptidase activity
GO:0004181
2300
Serine-type carboxypeptidase activity
GO:0004185
6
Aspartic-type endopeptidase activity
GO:0004190
1831
Cysteine-type endopeptidase activity
GO:0004197
4962
Calcium-dependent cysteine-type endopeptidase activity
GO:0004198
382
Ubiquitin thiolesterase activity
GO:0004221
4219
Metalloendopeptidase activity
GO:0004222
3409
Serine-type endopeptidase activity
GO:0004252
3227
Threonine-type endopeptidase activity
GO:0004298
1612
Enoyl-CoA hydratase activity
GO:0004300
292
Epoxide hydrolase activity
GO:0004301
147
Estradiol 17-beta-dehydrogenase activity
GO:0004303
549
Estrone sulfotransferase activity
GO:0004304
130
Ethanolamine kinase activity
GO:0004305
6
Ethanolamine-phosphate cytidylyltransferase activity
GO:0004306
1
Ethanolaminephosphotransferase activity
GO:0004307
470
Exo-alpha-sialidase activity
GO:0004308
3
Farnesyl-diphosphate farnesyltransferase activity
GO:0004310
10
Farnesyltranstransferase activity
GO:0004311
750
Oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0004320
675
Ferroxidase activity
GO:0004322
1946
Ferredoxin-NADP+ reductase activity
GO:0004324
2
Ferrochelatase activity
GO:0004325
1061
Tetrahydrofolylpolyglutamate synthase activity
GO:0004326
2
Formate-tetrahydrofolate ligase activity
GO:0004329
114
Fructose-2,6-bisphosphate 2-phosphatase activity
GO:0004331
145
Fructose-bisphosphate aldolase activity
GO:0004332
7
Fumarate hydratase activity
GO:0004333
2
Fumarylacetoacetase activity
GO:0004334
1
Galactokinase activity
GO:0004335
215
Galactosylceramidase activity
GO:0004336
8
Geranyltranstransferase activity
GO:0004337
750
Glucokinase activity
GO:0004340
274
Glucosamine-6-phosphate deaminase activity
GO:0004342
3
Glucosamine 6-phosphate N-acetyltransferase activity
GO:0004343
894
Glucose-6-phosphate dehydrogenase activity
GO:0004345
6
Glucose-6-phosphatase activity
GO:0004346
816
Glucose-6-phosphate isomerase activity
GO:0004347
1415
Glucosylceramidase activity
GO:0004348
3
Glutamate 5-kinase activity
GO:0004349
5
Glutamate-5-semialdehyde dehydrogenase activity
GO:0004350
5
Glutamate decarboxylase activity
GO:0004351
14
Glutamate dehydrogenase (NAD+) activity
GO:0004352
4
Glutamate dehydrogenase [NAD(P)+] activity
GO:0004353
4
Glutamate-ammonia ligase activity
GO:0004356
779
Glutamate-cysteine ligase activity
GO:0004357
1043
Glutaminase activity
GO:0004359
14
Glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0004360
1346
Glutaryl-CoA dehydrogenase activity
GO:0004361
1
Glutathione-disulfide reductase activity
GO:0004362
457
Glutathione synthase activity
GO:0004363
2
Glutathione transferase activity
GO:0004364
1139
Glycerol-3-phosphate O-acyltransferase activity
GO:0004366
542
Glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0004367
6
Glycerol-3-phosphate dehydrogenase activity
GO:0004368
9
Glycerol kinase activity
GO:0004370
2355
Glycine hydroxymethyltransferase activity
GO:0004372
9
Glycogen (starch) synthase activity
GO:0004373
4
Glycine dehydrogenase (decarboxylating) activity
GO:0004375
3
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0004378
3
Glycylpeptide N-tetradecanoyltransferase activity
GO:0004379
1458
Guanosine-diphosphatase activity
GO:0004382
3
Guanylate cyclase activity
GO:0004383
86
Guanylate kinase activity
GO:0004385
48
Helicase activity
GO:0004386
3384
Heme oxygenase (decyclizing) activity
GO:0004392
694
Hexaprenyldihydroxybenzoate methyltransferase activity
GO:0004395
4
Hexokinase activity
GO:0004396
269
Histidine ammonia-lyase activity
GO:0004397
4
Histidine decarboxylase activity
GO:0004398
2
Histone acetyltransferase activity
GO:0004402
2606
Histone deacetylase activity
GO:0004407
1205
Holocytochrome-c synthase activity
GO:0004408
3
Homogentisate 1,2-dioxygenase activity
GO:0004411
1
Hyalurononglucosaminidase activity
GO:0004415
468
Hydroxyacylglutathione hydrolase activity
GO:0004416
9
Hydroxymethylbilane synthase activity
GO:0004418
7
Hydroxymethylglutaryl-CoA lyase activity
GO:0004419
5
Hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0004420
4
Hydroxymethylglutaryl-CoA synthase activity
GO:0004421
7
Iduronate-2-sulfatase activity
GO:0004423
1038
Inorganic diphosphatase activity
GO:0004427
527
1-phosphatidylinositol 4-kinase activity
GO:0004430
13
Phosphatidylinositol phospholipase C activity
GO:0004435
2080
Phosphatidylinositol-3-phosphatase activity
GO:0004438
304
Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004439
975
Inositol-1,4-bisphosphate 1-phosphatase activity
GO:0004441
2
Inositol-polyphosphate 5-phosphatase activity
GO:0004445
22
Iodide peroxidase activity
GO:0004447
759
Isocitrate dehydrogenase (NAD+) activity
GO:0004449
4
Isopentenyl-diphosphate delta-isomerase activity
GO:0004452
4
L-lactate dehydrogenase activity
GO:0004459
186
Lactose synthase activity
GO:0004461
7
Lactoylglutathione lyase activity
GO:0004462
2
Leukotriene-A4 hydrolase activity
GO:0004463
146
Leukotriene-C4 synthase activity
GO:0004464
1
Lipoprotein lipase activity
GO:0004465
11
Long-chain-acyl-CoA dehydrogenase activity
GO:0004466
5
Long-chain fatty acid-CoA ligase activity
GO:0004467
1023
Lysine N-acetyltransferase activity
GO:0004468
131
Malic enzyme activity
GO:0004470
7
Malate dehydrogenase (decarboxylating) activity
GO:0004471
933
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0004473
7
Mannose-6-phosphate isomerase activity
GO:0004476
568
Methenyltetrahydrofolate cyclohydrolase activity
GO:0004477
114
Methionine adenosyltransferase activity
GO:0004478
4
Methionyl-tRNA formyltransferase activity
GO:0004479
1421
MRNA (guanine-N7-)-methyltransferase activity
GO:0004482
6
Methylcrotonoyl-CoA carboxylase activity
GO:0004485
342
Methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004487
2
Methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0004488
114
Methylglutaconyl-CoA hydratase activity
GO:0004490
1
Methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0004491
1616
Methylmalonyl-CoA decarboxylase activity
GO:0004492
1
Methylmalonyl-CoA mutase activity
GO:0004494
4
Mevalonate kinase activity
GO:0004496
1
Monooxygenase activity
GO:0004497
3525
Calcidiol 1-monooxygenase activity
GO:0004498
3
N,N-dimethylaniline monooxygenase activity
GO:0004499
9
Dopamine beta-monooxygenase activity
GO:0004500
2
Kynurenine 3-monooxygenase activity
GO:0004502
193
Monophenol monooxygenase activity
GO:0004503
4
Peptidylglycine monooxygenase activity
GO:0004504
38
Phenylalanine 4-monooxygenase activity
GO:0004505
4
Squalene monooxygenase activity
GO:0004506
4
Steroid 11-beta-monooxygenase activity
GO:0004507
3
Steroid 17-alpha-monooxygenase activity
GO:0004508
4
Steroid 21-monooxygenase activity
GO:0004509
2
Tryptophan 5-monooxygenase activity
GO:0004510
10
Tyrosine 3-monooxygenase activity
GO:0004511
2
Inositol-3-phosphate synthase activity
GO:0004512
1
Nicotinate-nucleotide adenylyltransferase activity
GO:0004515
22
Nitric-oxide synthase activity
GO:0004517
1487
Nuclease activity
GO:0004518
424
Endonuclease activity
GO:0004519
3138
Endodeoxyribonuclease activity
GO:0004520
1746
Endoribonuclease activity
GO:0004521
37
Ribonuclease H activity
GO:0004523
275
Ribonuclease III activity
GO:0004525
489
Ribonuclease P activity
GO:0004526
1650
Exonuclease activity
GO:0004527
592
Phosphodiesterase I activity
GO:0004528
830
Deoxyribonuclease I activity
GO:0004530
720
Deoxyribonuclease II activity
GO:0004531
625
Exoribonuclease activity
GO:0004532
1204
5'-3' exoribonuclease activity
GO:0004534
4
Poly(A)-specific ribonuclease activity
GO:0004535
967
Deoxyribonuclease activity
GO:0004536
1847
Ribonuclease activity
GO:0004540
1611
Nucleoside diphosphate kinase activity
GO:0004550
643
Nucleotide diphosphatase activity
GO:0004551
824
Hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004553
3081
Alpha-galactosidase activity
GO:0004557
4
Alpha-glucosidase activity
GO:0004558
8
Alpha-mannosidase activity
GO:0004559
608
Alpha-L-fucosidase activity
GO:0004560
3
Alpha-N-acetylglucosaminidase activity
GO:0004561
3
Beta-N-acetylhexosaminidase activity
GO:0004563
3
Beta-galactosidase activity
GO:0004565
1314
Beta-glucuronidase activity
GO:0004566
1124
Chitinase activity
GO:0004568
203
Glycoprotein endo-alpha-1,2-mannosidase activity
GO:0004569
4
Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0004571
1278
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0004572
600
Oligo-1,6-glucosidase activity
GO:0004574
2
Sucrose alpha-glucosidase activity
GO:0004575
2
Oligosaccharyl transferase activity
GO:0004576
981
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
GO:0004577
3
Dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0004579
1142
Dolichyl-phosphate beta-glucosyltransferase activity
GO:0004581
1
Dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0004582
4
Ornithine decarboxylase activity
GO:0004586
1
Orotate phosphoribosyltransferase activity
GO:0004588
594
Orotidine-5'-phosphate decarboxylase activity
GO:0004590
594
Oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0004591
1300
Pantothenate kinase activity
GO:0004594
736
Pantetheine-phosphate adenylyltransferase activity
GO:0004595
1
Peptide-aspartate beta-dioxygenase activity
GO:0004597
12
Peptidylamidoglycolate lyase activity
GO:0004598
38
Peroxidase activity
GO:0004601
1359
Glutathione peroxidase activity
GO:0004602
790
Phenylethanolamine N-methyltransferase activity
GO:0004603
2
Phosphatidate cytidylyltransferase activity
GO:0004605
14
Phosphatidylethanolamine N-methyltransferase activity
GO:0004608
1
Phosphatidylserine decarboxylase activity
GO:0004609
4
Phosphoacetylglucosamine mutase activity
GO:0004610
4
Phosphoenolpyruvate carboxykinase activity
GO:0004611
5
Phosphoenolpyruvate carboxykinase (GTP) activity
GO:0004613
20
Phosphoglucomutase activity
GO:0004614
12
Phosphomannomutase activity
GO:0004615
1
Phosphogluconate dehydrogenase (decarboxylating) activity
GO:0004616
1
Phosphoglycerate kinase activity
GO:0004618
5
Phosphoglycerate mutase activity
GO:0004619
1
Phospholipase activity
GO:0004620
205
Glycosylphosphatidylinositol phospholipase D activity
GO:0004621
823
Lysophospholipase activity
GO:0004622
33
Phospholipase A2 activity
GO:0004623
1545
Phospholipase C activity
GO:0004629
47
Phospholipase D activity
GO:0004630
843
Phosphopantothenate--cysteine ligase activity
GO:0004632
3
Phosphopantothenoylcysteine decarboxylase activity
GO:0004633
2
Phosphoribosylamine-glycine ligase activity
GO:0004637
317
Phosphoribosylaminoimidazole carboxylase activity
GO:0004638
857
Phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0004639
857
Phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004641
317
Phosphoribosylformylglycinamidine synthase activity
GO:0004642
604
Phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0004643
2
Phosphoribosylglycinamide formyltransferase activity
GO:0004644
317
Phosphorylase activity
GO:0004645
563
Phosphoserine phosphatase activity
GO:0004647
4
Poly(ADP-ribose) glycohydrolase activity
GO:0004649
4
Polynucleotide 5'-phosphatase activity
GO:0004651
1
Polynucleotide adenylyltransferase activity
GO:0004652
189
Polypeptide N-acetylgalactosaminyltransferase activity
GO:0004653
1657
Porphobilinogen synthase activity
GO:0004655
2
Procollagen-proline 4-dioxygenase activity
GO:0004656
109
Proline dehydrogenase activity
GO:0004657
61
Propionyl-CoA carboxylase activity
GO:0004658
36
Prenyltransferase activity
GO:0004659
668
Protein farnesyltransferase activity
GO:0004660
1
Protein geranylgeranyltransferase activity
GO:0004661
3
CAAX-protein geranylgeranyltransferase activity
GO:0004662
3
Rab geranylgeranyltransferase activity
GO:0004663
719
Prostaglandin-endoperoxide synthase activity
GO:0004666
14
Prostaglandin-D synthase activity
GO:0004667
2
Protein-arginine deiminase activity
GO:0004668
13
Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0004671
1626
Protein kinase activity
GO:0004672
5973
Protein serine/threonine kinase activity
GO:0004674
6614
Transmembrane receptor protein serine/threonine kinase activity
GO:0004675
488
3-phosphoinositide-dependent protein kinase activity
GO:0004676
7
DNA-dependent protein kinase activity
GO:0004677
2029
AMP-activated protein kinase activity
GO:0004679
931
Calmodulin-dependent protein kinase activity
GO:0004683
2674
Elongation factor-2 kinase activity
GO:0004686
1822
Myosin light chain kinase activity
GO:0004687
1887
Phosphorylase kinase activity
GO:0004689
1591
CAMP-dependent protein kinase activity
GO:0004691
1525
CGMP-dependent protein kinase activity
GO:0004692
11
Cyclin-dependent protein kinase activity
GO:0004693
2239
Eukaryotic translation initiation factor 2alpha kinase activity
GO:0004694
947
Protein kinase C activity
GO:0004697
943
Calcium-dependent protein kinase C activity
GO:0004698
894
Calcium-independent protein kinase C activity
GO:0004699
6
Receptor signaling protein serine/threonine kinase activity
GO:0004702
1447
G-protein coupled receptor kinase activity
GO:0004703
18
NF-kappaB-inducing kinase activity
GO:0004704
285
JUN kinase activity
GO:0004705
22
JUN kinase kinase kinase activity
GO:0004706
653
MAP kinase activity
GO:0004707
1086
MAP kinase kinase activity
GO:0004708
686
MAP kinase kinase kinase activity
GO:0004709
1766
Ribosomal protein S6 kinase activity
GO:0004711
10
Protein serine/threonine/tyrosine kinase activity
GO:0004712
1428
Protein tyrosine kinase activity
GO:0004713
4260
Transmembrane receptor protein tyrosine kinase activity
GO:0004714
1197
Non-membrane spanning protein tyrosine kinase activity
GO:0004715
3471
Receptor signaling protein tyrosine kinase activity
GO:0004716
739
Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0004719
15
Protein-lysine 6-oxidase activity
GO:0004720
6
Phosphoprotein phosphatase activity
GO:0004721
2882
Protein serine/threonine phosphatase activity
GO:0004722
3873
Calcium-dependent protein serine/threonine phosphatase activity
GO:0004723
10
Magnesium-dependent protein serine/threonine phosphatase activity
GO:0004724
1719
Protein tyrosine phosphatase activity
GO:0004725
3739
Non-membrane spanning protein tyrosine phosphatase activity
GO:0004726
280
Prenylated protein tyrosine phosphatase activity
GO:0004727
4
Receptor signaling protein tyrosine phosphatase activity
GO:0004728
1
Oxygen-dependent protoporphyrinogen oxidase activity
GO:0004729
3
Purine-nucleoside phosphorylase activity
GO:0004731
569
Pyridoxamine-phosphate oxidase activity
GO:0004733
1135
Pyrroline-5-carboxylate reductase activity
GO:0004735
6
Pyruvate carboxylase activity
GO:0004736
3
Pyruvate dehydrogenase activity
GO:0004738
229
Pyruvate dehydrogenase (acetyl-transferring) activity
GO:0004739
229
Pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0004740
1184
[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0004741
1721
Pyruvate kinase activity
GO:0004743
9
Retinal isomerase activity
GO:0004744
5
Retinol dehydrogenase activity
GO:0004745
1100
Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0004748
516
Ribose phosphate diphosphokinase activity
GO:0004749
9
Ribulose-phosphate 3-epimerase activity
GO:0004750
53
Ribose-5-phosphate isomerase activity
GO:0004751
3
Selenide, water dikinase activity
GO:0004756
3
Serine C-palmitoyltransferase activity
GO:0004758
2011
Serine-pyruvate transaminase activity
GO:0004760
2
Spermidine synthase activity
GO:0004766
2
Sphingomyelin phosphodiesterase activity
GO:0004767
77
Stearoyl-CoA 9-desaturase activity
GO:0004768
822
Steroid delta-isomerase activity
GO:0004769
1
Sterol esterase activity
GO:0004771
7
Sterol O-acyltransferase activity
GO:0004772
1407
Steryl-sulfatase activity
GO:0004773
3
Succinate-CoA ligase (ADP-forming) activity
GO:0004775
5
Succinate-CoA ligase (GDP-forming) activity
GO:0004776
4
Succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0004777
708
Succinyl-CoA hydrolase activity
GO:0004778
2
Sulfate adenylyltransferase (ATP) activity
GO:0004781
9
Sulfinoalanine decarboxylase activity
GO:0004782
591
Superoxide dismutase activity
GO:0004784
685
Thiamine diphosphokinase activity
GO:0004788
1
Thioether S-methyltransferase activity
GO:0004790
1026
Thioredoxin-disulfide reductase activity
GO:0004791
1301
Thiosulfate sulfurtransferase activity
GO:0004792
3
L-threonine ammonia-lyase activity
GO:0004794
360
Thromboxane-A synthase activity
GO:0004796
1
Thymidine kinase activity
GO:0004797
106
Thymidylate kinase activity
GO:0004798
2
Thyroxine 5'-deiodinase activity
GO:0004800
11
Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
GO:0004801
2
Transketolase activity
GO:0004802
38
Transposase activity
GO:0004803
874
Triglyceride lipase activity
GO:0004806
658
Triose-phosphate isomerase activity
GO:0004807
1
TRNA (guanine-N2-)-methyltransferase activity
GO:0004809
9
Aminoacyl-tRNA ligase activity
GO:0004812
22
Alanine-tRNA ligase activity
GO:0004813
784
Arginine-tRNA ligase activity
GO:0004814
1
Aspartate-tRNA ligase activity
GO:0004815
4
Asparagine-tRNA ligase activity
GO:0004816
6
Cysteine-tRNA ligase activity
GO:0004817
1
Glutamate-tRNA ligase activity
GO:0004818
6
Glutamine-tRNA ligase activity
GO:0004819
6
Glycine-tRNA ligase activity
GO:0004820
1
Histidine-tRNA ligase activity
GO:0004821
4
Isoleucine-tRNA ligase activity
GO:0004822
5
Methionine-tRNA ligase activity
GO:0004825
9
Phenylalanine-tRNA ligase activity
GO:0004826
640
Proline-tRNA ligase activity
GO:0004827
5
Serine-tRNA ligase activity
GO:0004828
2
Threonine-tRNA ligase activity
GO:0004829
811
Tryptophan-tRNA ligase activity
GO:0004830
4
Tyrosine-tRNA ligase activity
GO:0004831
478
Valine-tRNA ligase activity
GO:0004832
5
Tryptophan 2,3-dioxygenase activity
GO:0004833
3
Tubulin-tyrosine ligase activity
GO:0004835
115
L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0004838
746
Ubiquitin activating enzyme activity
GO:0004839
9
Ubiquitin-protein ligase activity
GO:0004842
6150
Ubiquitin-specific protease activity
GO:0004843
4431
Uracil DNA N-glycosylase activity
GO:0004844
685
Uridine kinase activity
GO:0004849
12
Uridine phosphorylase activity
GO:0004850
6
Uroporphyrinogen-III synthase activity
GO:0004852
2
Uroporphyrinogen decarboxylase activity
GO:0004853
1
Xanthine dehydrogenase activity
GO:0004854
252
Xanthine oxidase activity
GO:0004855
243
Xylulokinase activity
GO:0004856
2
Enzyme inhibitor activity
GO:0004857
225
Phospholipase inhibitor activity
GO:0004859
16
Protein kinase inhibitor activity
GO:0004860
2703
Cyclin-dependent protein kinase inhibitor activity
GO:0004861
321
CAMP-dependent protein kinase inhibitor activity
GO:0004862
305
Protein phosphatase inhibitor activity
GO:0004864
1152
Protein serine/threonine phosphatase inhibitor activity
GO:0004865
26
Endopeptidase inhibitor activity
GO:0004866
906
Serine-type endopeptidase inhibitor activity
GO:0004867
3097
Cysteine-type endopeptidase inhibitor activity
GO:0004869
360
Signal transducer activity
GO:0004871
5555
Receptor activity
GO:0004872
5808
Asialoglycoprotein receptor activity
GO:0004873
2553
Aryl hydrocarbon receptor activity
GO:0004874
73
Complement receptor activity
GO:0004875
6
Complement component C3b receptor activity
GO:0004877
806
Complement component C5a receptor activity
GO:0004878
342
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004879
2905
Androgen receptor activity
GO:0004882
18
Glucocorticoid receptor activity
GO:0004883
9
9-cis retinoic acid receptor activity
GO:0004886
8
Thyroid hormone receptor activity
GO:0004887
149
Transmembrane signaling receptor activity
GO:0004888
4614
Acetylcholine-activated cation-selective channel activity
GO:0004889
1911
GABA-A receptor activity
GO:0004890
107
Cytokine receptor activity
GO:0004896
3275
Ciliary neurotrophic factor receptor activity
GO:0004897
1371
Erythropoietin receptor activity
GO:0004900
5
Interferon receptor activity
GO:0004904
1139
Type I interferon receptor activity
GO:0004905
1632
Interferon-gamma receptor activity
GO:0004906
121
Interleukin-1 receptor activity
GO:0004908
528
Interleukin-1, Type I, activating receptor activity
GO:0004909
506
Interleukin-1, Type II, blocking receptor activity
GO:0004910
5
Interleukin-2 receptor activity
GO:0004911
237
Interleukin-3 receptor activity
GO:0004912
9
Interleukin-4 receptor activity
GO:0004913
191
Interleukin-5 receptor activity
GO:0004914
229
Interleukin-6 receptor activity
GO:0004915
1362
Interleukin-7 receptor activity
GO:0004917
5
Interleukin-10 receptor activity
GO:0004920
452
Interleukin-11 receptor activity
GO:0004921
6
Leukemia inhibitory factor receptor activity
GO:0004923
14
Oncostatin-M receptor activity
GO:0004924
894
Prolactin receptor activity
GO:0004925
109
G-protein coupled receptor activity
GO:0004930
5785
Extracellular ATP-gated cation channel activity
GO:0004931
21
Alpha1-adrenergic receptor activity
GO:0004937
940
Alpha2-adrenergic receptor activity
GO:0004938
11
Beta-adrenergic receptor activity
GO:0004939
18
Beta1-adrenergic receptor activity
GO:0004940
5
Beta2-adrenergic receptor activity
GO:0004941
1
C5a anaphylatoxin receptor activity
GO:0004944
342
Angiotensin type II receptor activity
GO:0004945
10
Bombesin receptor activity
GO:0004946
1
Bradykinin receptor activity
GO:0004947
46
Calcitonin receptor activity
GO:0004948
11
Cannabinoid receptor activity
GO:0004949
13
Chemokine receptor activity
GO:0004950
1712
Cholecystokinin receptor activity
GO:0004951
4
Dopamine receptor activity
GO:0004952
13
Prostaglandin D receptor activity
GO:0004956
7
Prostaglandin E receptor activity
GO:0004957
16
Prostaglandin F receptor activity
GO:0004958
7
Thromboxane receptor activity
GO:0004960
1067
Thromboxane A2 receptor activity
GO:0004961
1067
Endothelin receptor activity
GO:0004962
8
Follicle-stimulating hormone receptor activity
GO:0004963
2
Luteinizing hormone receptor activity
GO:0004964
3
G-protein coupled GABA receptor activity
GO:0004965
26
Glucagon receptor activity
GO:0004967
10
Gonadotropin-releasing hormone receptor activity
GO:0004968
12
Histamine receptor activity
GO:0004969
1350
Ionotropic glutamate receptor activity
GO:0004970
204
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0004971
35
N-methyl-D-aspartate selective glutamate receptor activity
GO:0004972
161
Leukotriene receptor activity
GO:0004974
634
Melanocortin receptor activity
GO:0004977
16
Corticotropin receptor activity
GO:0004978
11
Beta-endorphin receptor activity
GO:0004979
1710
Melanocyte-stimulating hormone receptor activity
GO:0004980
5
Neuropeptide Y receptor activity
GO:0004983
1467
Olfactory receptor activity
GO:0004984
1814
Opioid receptor activity
GO:0004985
820
Oxytocin receptor activity
GO:0004990
16
Platelet activating factor receptor activity
GO:0004992
1118
Serotonin receptor activity
GO:0004993
695
Somatostatin receptor activity
GO:0004994
675
Tachykinin receptor activity
GO:0004995
23
Thyroid-stimulating hormone receptor activity
GO:0004996
5
Transferrin receptor activity
GO:0004998
7
Vasoactive intestinal polypeptide receptor activity
GO:0004999
938
Vasopressin receptor activity
GO:0005000
705
Transmembrane receptor protein tyrosine phosphatase activity
GO:0005001
605
Ephrin receptor activity
GO:0005003
928
GPI-linked ephrin receptor activity
GO:0005004
180
Transmembrane-ephrin receptor activity
GO:0005005
807
Epidermal growth factor-activated receptor activity
GO:0005006
9
Fibroblast growth factor-activated receptor activity
GO:0005007
1065
Hepatocyte growth factor-activated receptor activity
GO:0005008
353
Insulin-activated receptor activity
GO:0005009
8
Insulin-like growth factor-activated receptor activity
GO:0005010
55
Macrophage colony-stimulating factor receptor activity
GO:0005011
12
Platelet-derived growth factor alpha-receptor activity
GO:0005018
11
Platelet-derived growth factor beta-receptor activity
GO:0005019
3
Stem cell factor receptor activity
GO:0005020
6
Vascular endothelial growth factor-activated receptor activity
GO:0005021
754
Transforming growth factor beta-activated receptor activity
GO:0005024
1385
Transforming growth factor beta receptor activity, type I
GO:0005025
479
Transforming growth factor beta receptor activity, type II
GO:0005026
5
Neurotrophin receptor activity
GO:0005030
7
Tumor necrosis factor-activated receptor activity
GO:0005031
831
Osmosensor activity
GO:0005034
1
Death receptor activity
GO:0005035
321
Low-density lipoprotein receptor activity
GO:0005041
2042
Netrin receptor activity
GO:0005042
20
Scavenger receptor activity
GO:0005044
2115
KDEL sequence binding
GO:0005046
5
Signal recognition particle binding
GO:0005047
103
Signal sequence binding
GO:0005048
7
Peroxisome matrix targeting signal-1 binding
GO:0005052
625
Laminin receptor activity
GO:0005055
8
Receptor signaling protein activity
GO:0005057
1816
Transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005068
148
SH3/SH2 adaptor activity
GO:0005070
3274
Transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005072
11
MAP-kinase scaffold activity
GO:0005078
2183
Protein kinase C binding
GO:0005080
2876
Small GTPase regulator activity
GO:0005083
2308
Guanyl-nucleotide exchange factor activity
GO:0005085
3717
ARF guanyl-nucleotide exchange factor activity
GO:0005086
975
Ran guanyl-nucleotide exchange factor activity
GO:0005087
249
Ras guanyl-nucleotide exchange factor activity
GO:0005088
845
Rho guanyl-nucleotide exchange factor activity
GO:0005089
3974
GDP-dissociation inhibitor activity
GO:0005092
14
Rab GDP-dissociation inhibitor activity
GO:0005093
3
Rho GDP-dissociation inhibitor activity
GO:0005094
8
GTPase inhibitor activity
GO:0005095
211
GTPase activator activity
GO:0005096
3981
Rab GTPase activator activity
GO:0005097
3605
Ran GTPase activator activity
GO:0005098
145
Ras GTPase activator activity
GO:0005099
997
Rho GTPase activator activity
GO:0005100
1555
Receptor binding
GO:0005102
5724
Fibroblast growth factor receptor binding
GO:0005104
826
Type 1 fibroblast growth factor receptor binding
GO:0005105
15
Frizzled binding
GO:0005109
872
Frizzled-2 binding
GO:0005110
2
Type 2 fibroblast growth factor receptor binding
GO:0005111
10
Notch binding
GO:0005112
1795
Patched binding
GO:0005113
35
Type II transforming growth factor beta receptor binding
GO:0005114
47
Smoothened binding
GO:0005119
30
Toll binding
GO:0005121
2
Death receptor binding
GO:0005123
2366
Cytokine activity
GO:0005125
4068
Cytokine receptor binding
GO:0005126
10
Ciliary neurotrophic factor receptor binding
GO:0005127
21
Erythropoietin receptor binding
GO:0005128
1131
Granulocyte colony-stimulating factor receptor binding
GO:0005130
1
Growth hormone receptor binding
GO:0005131
19
Interferon-alpha/beta receptor binding
GO:0005132
4
Interleukin-2 receptor binding
GO:0005134
407
Interleukin-3 receptor binding
GO:0005135
1133
Interleukin-4 receptor binding
GO:0005136
1
Interleukin-6 receptor binding
GO:0005138
1484
Interleukin-7 receptor binding
GO:0005139
3
Interleukin-10 receptor binding
GO:0005141
576
Interleukin-11 receptor binding
GO:0005142
893
Interleukin-12 receptor binding
GO:0005143
1084
Interleukin-13 receptor binding
GO:0005144
2
Leukemia inhibitory factor receptor binding
GO:0005146
356
Oncostatin-M receptor binding
GO:0005147
1
Prolactin receptor binding
GO:0005148
392
Interleukin-1 receptor binding
GO:0005149
1643
Interleukin-1, Type I receptor binding
GO:0005150
1
Interleukin-1, Type II receptor binding
GO:0005151
6
Interleukin-1 receptor antagonist activity
GO:0005152
13
Epidermal growth factor receptor binding
GO:0005154
2109
Macrophage colony-stimulating factor receptor binding
GO:0005157
14
Insulin receptor binding
GO:0005158
1774
Insulin-like growth factor receptor binding
GO:0005159
829
Transforming growth factor beta receptor binding
GO:0005160
2827
Platelet-derived growth factor receptor binding
GO:0005161
592
Tumor necrosis factor receptor binding
GO:0005164
1961
Neurotrophin p75 receptor binding
GO:0005166
1
Neurotrophin TRKA receptor binding
GO:0005168
820
Neurotrophin TRKB receptor binding
GO:0005169
3
Vascular endothelial growth factor receptor binding
GO:0005172
8
Stem cell factor receptor binding
GO:0005173
981
CD40 receptor binding
GO:0005174
6
ErbB-2 class receptor binding
GO:0005176
6
Integrin binding
GO:0005178
3885
Hormone activity
GO:0005179
3230
Neuropeptide hormone activity
GO:0005184
16
Neurohypophyseal hormone activity
GO:0005185
1
Structural molecule activity
GO:0005198
4535
Structural constituent of cell wall
GO:0005199
6
Structural constituent of cytoskeleton
GO:0005200
2147
Extracellular matrix structural constituent
GO:0005201
2473
Structural constituent of eye lens
GO:0005212
114
Transporter activity
GO:0005215
5351
Ion channel activity
GO:0005216
3816
Intracellular ligand-gated calcium channel activity
GO:0005218
19
Ryanodine-sensitive calcium-release channel activity
GO:0005219
53
Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005220
23
Intracellular cAMP activated cation channel activity
GO:0005222
1181
Intracellular cGMP activated cation channel activity
GO:0005223
833
ATP-binding and phosphorylation-dependent chloride channel activity
GO:0005224
11
Calcium activated cation channel activity
GO:0005227
707
Intracellular calcium activated chloride channel activity
GO:0005229
701
Extracellular ligand-gated ion channel activity
GO:0005230
1041
Excitatory extracellular ligand-gated ion channel activity
GO:0005231
907
Serotonin-activated cation-selective channel activity
GO:0005232
168
Extracellular-glutamate-gated ion channel activity
GO:0005234
220
Inhibitory extracellular ligand-gated ion channel activity
GO:0005237
8
Inward rectifier potassium channel activity
GO:0005242
876
Gap junction channel activity
GO:0005243
2327
Voltage-gated ion channel activity
GO:0005244
915
Voltage-gated calcium channel activity
GO:0005245
3037
Calcium channel regulator activity
GO:0005246
2088
Voltage-gated chloride channel activity
GO:0005247
1312
Voltage-gated sodium channel activity
GO:0005248
2123
Voltage-gated potassium channel activity
GO:0005249
2212
A-type (transient outward) potassium channel activity
GO:0005250
12
Delayed rectifier potassium channel activity
GO:0005251
131
Open rectifier potassium channel activity
GO:0005252
156
Anion channel activity
GO:0005253
794
Chloride channel activity
GO:0005254
2648
Channel-conductance-controlling ATPase activity
GO:0005260
11
Cation channel activity
GO:0005261
806
Calcium channel activity
GO:0005262
3434
Potassium channel activity
GO:0005267
883
Sodium channel activity
GO:0005272
120
Amine transmembrane transporter activity
GO:0005275
8
Acetylcholine transmembrane transporter activity
GO:0005277
4
Hydrogen:amino acid symporter activity
GO:0005280
1058
Sodium:amino acid symporter activity
GO:0005283
21
High affinity arginine transmembrane transporter activity
GO:0005289
199
L-histidine transmembrane transporter activity
GO:0005290
12
Proline:sodium symporter activity
GO:0005298
9
Creatine transporter activity
GO:0005308
4
Creatine:sodium symporter activity
GO:0005309
4
Dicarboxylic acid transmembrane transporter activity
GO:0005310
4
L-glutamate transmembrane transporter activity
GO:0005313
234
High-affinity glutamate transmembrane transporter activity
GO:0005314
4
Inorganic phosphate transmembrane transporter activity
GO:0005315
8
High affinity inorganic phosphate:sodium symporter activity
GO:0005316
2
Lipid transporter activity
GO:0005319
2108
Long-chain fatty acid transporter activity
GO:0005324
4
Peroxisomal fatty-acyl-CoA transporter activity
GO:0005325
4
Neurotransmitter transporter activity
GO:0005326
18
Neurotransmitter:sodium symporter activity
GO:0005328
1221
Dopamine transmembrane transporter activity
GO:0005329
8
Dopamine:sodium symporter activity
GO:0005330
3
Gamma-aminobutyric acid:sodium symporter activity
GO:0005332
3
Norepinephrine transmembrane transporter activity
GO:0005333
10
Norepinephrine:sodium symporter activity
GO:0005334
7
Serotonin:sodium symporter activity
GO:0005335
1036
Nucleoside transmembrane transporter activity
GO:0005337
18
Nucleotide-sugar transmembrane transporter activity
GO:0005338
12
Oxygen transporter activity
GO:0005344
548
Purine base transmembrane transporter activity
GO:0005345
2
ATP transmembrane transporter activity
GO:0005347
7
Pyrimidine base transmembrane transporter activity
GO:0005350
2
Sugar:hydrogen symporter activity
GO:0005351
812
Fructose transmembrane transporter activity
GO:0005353
4
Glucose transmembrane transporter activity
GO:0005355
1284
Taurine:sodium symporter activity
GO:0005369
16
Water transmembrane transporter activity
GO:0005372
897
Copper ion transmembrane transporter activity
GO:0005375
1866
Iron ion transmembrane transporter activity
GO:0005381
7
Manganese ion transmembrane transporter activity
GO:0005384
719
Zinc ion transmembrane transporter activity
GO:0005385
1780
Calcium-transporting ATPase activity
GO:0005388
85
Sodium:potassium-exchanging ATPase activity
GO:0005391
1271
Glucose:sodium symporter activity
GO:0005412
82
Nucleoside:sodium symporter activity
GO:0005415
760
Proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0005427
1042
Calcium:sodium antiporter activity
GO:0005432
227
Sodium:phosphate symporter activity
GO:0005436
103
Inorganic anion exchanger activity
GO:0005452
2804
CMP-N-acetylneuraminate transmembrane transporter activity
GO:0005456
2
UDP-galactose transmembrane transporter activity
GO:0005459
11
Pyruvate secondary active transmembrane transporter activity
GO:0005477
786
Soluble NSF attachment protein activity
GO:0005483
164
SNAP receptor activity
GO:0005484
3368
Nucleocytoplasmic transporter activity
GO:0005487
1120
Steroid binding
GO:0005496
1837
Androgen binding
GO:0005497
23
Vitamin D binding
GO:0005499
8
Retinoid binding
GO:0005501
539
11-cis retinal binding
GO:0005502
7
All-trans retinal binding
GO:0005503
9
Fatty acid binding
GO:0005504
2106
Iron ion binding
GO:0005506
5289
Copper ion binding
GO:0005507
1480
Calcium ion binding
GO:0005509
7259
Protein binding
GO:0005515
10348
Calmodulin binding
GO:0005516
5247
Collagen binding
GO:0005518
3298
Cytoskeletal regulatory protein binding
GO:0005519
5
Insulin-like growth factor binding
GO:0005520
401
Lamin binding
GO:0005521
1207
Profilin binding
GO:0005522
59
Tropomyosin binding
GO:0005523
834
ATP binding
GO:0005524
8575
GTP binding
GO:0005525
6438
Macrolide binding
GO:0005527
5
FK506 binding
GO:0005528
1810
Galactose binding
GO:0005534
12
Glucose binding
GO:0005536
280
Mannose binding
GO:0005537
1188
Glycosaminoglycan binding
GO:0005539
78
Hyaluronic acid binding
GO:0005540
879
Folic acid binding
GO:0005542
209
Phospholipid binding
GO:0005543
3543
Calcium-dependent phospholipid binding
GO:0005544
1520
1-phosphatidylinositol binding
GO:0005545
3095
Phosphatidylinositol-4,5-bisphosphate binding
GO:0005546
1577
Phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005547
1489
Phospholipid transporter activity
GO:0005548
20
Chemokine activity
GO:0008009
2969
Beta-catenin binding
GO:0008013
2208
Microtubule binding
GO:0008017
5879
G-protein coupled photoreceptor activity
GO:0008020
24
Protein C-terminus binding
GO:0008022
4322
ATP-dependent helicase activity
GO:0008026
3459
Monocarboxylic acid transmembrane transporter activity
GO:0008028
65
High-density lipoprotein particle binding
GO:0008035
1276
Axon guidance receptor activity
GO:0008046
368
Enzyme activator activity
GO:0008047
3225
Calcium sensitive guanylate cyclase activator activity
GO:0008048
770
ARF GTPase activator activity
GO:0008060
136
Chitin binding
GO:0008061
206
Glutamate receptor activity
GO:0008066
999
Translation termination factor activity
GO:0008079
4
N-acetyltransferase activity
GO:0008080
1491
Phosphoric diester hydrolase activity
GO:0008081
1072
Growth factor activity
GO:0008083
4206
Cytoskeletal protein binding
GO:0008092
2455
Cytoskeletal adaptor activity
GO:0008093
1892
DNA-dependent ATPase activity
GO:0008094
3472
5S rRNA binding
GO:0008097
5
Alcohol dehydrogenase (NADP+) activity
GO:0008106
2
Galactoside 2-alpha-L-fucosyltransferase activity
GO:0008107
2188
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008109
3
Alpha-methylacyl-CoA racemase activity
GO:0008111
121
Nicotinamide N-methyltransferase activity
GO:0008112
1
Peptide-methionine-(S)-S-oxide reductase activity
GO:0008113
3
Sarcosine oxidase activity
GO:0008115
566
Prostaglandin-I synthase activity
GO:0008116
1737
Sphinganine-1-phosphate aldolase activity
GO:0008117
548
Thiopurine S-methyltransferase activity
GO:0008119
1790
Ubiquinol-cytochrome-c reductase activity
GO:0008121
493
Cholesterol 7-alpha-monooxygenase activity
GO:0008123
131
4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO:0008124
1
Quercetin 2,3-dioxygenase activity
GO:0008127
3
Primary amine oxidase activity
GO:0008131
15
Transcription factor binding
GO:0008134
5662
Translation factor activity, nucleic acid binding
GO:0008135
3024
NADH dehydrogenase (ubiquinone) activity
GO:0008137
2066
Protein tyrosine/serine/threonine phosphatase activity
GO:0008138
1907
Nuclear localization sequence binding
GO:0008139
92
CAMP response element binding protein binding
GO:0008140
1722
Oxysterol binding
GO:0008142
31
Poly(A) RNA binding
GO:0008143
156
Drug binding
GO:0008144
2429
Sulfotransferase activity
GO:0008146
1923
Structural constituent of bone
GO:0008147
9
Protein phosphatase 1 binding
GO:0008157
2267
Hedgehog receptor activity
GO:0008158
1128
Protein tyrosine phosphatase activator activity
GO:0008160
3
Methyltransferase activity
GO:0008168
4487
N-methyltransferase activity
GO:0008170
7
O-methyltransferase activity
GO:0008171
833
RNA methyltransferase activity
GO:0008173
818
TRNA methyltransferase activity
GO:0008175
524
TRNA (guanine-N7-)-methyltransferase activity
GO:0008176
2
Succinate dehydrogenase (ubiquinone) activity
GO:0008177
104
Adenylate cyclase binding
GO:0008179
564
Glycogen phosphorylase activity
GO:0008184
13
RNA-dependent ATPase activity
GO:0008186
8
Poly-pyrimidine tract binding
GO:0008187
9
Neuropeptide receptor activity
GO:0008188
598
Eukaryotic initiation factor 4E binding
GO:0008190
590
Metalloendopeptidase inhibitor activity
GO:0008191
31
TRNA guanylyltransferase activity
GO:0008193
485
UDP-glycosyltransferase activity
GO:0008194
11
Phosphatidate phosphatase activity
GO:0008195
1683
Ferrous iron binding
GO:0008198
3174
Ferric iron binding
GO:0008199
1947
Ion channel inhibitor activity
GO:0008200
18
Heparin binding
GO:0008201
4124
G-protein coupled amine receptor activity
GO:0008227
10
Peptidase activity
GO:0008233
3484
Cysteine-type peptidase activity
GO:0008234
4499
Metalloexopeptidase activity
GO:0008235
17
Serine-type peptidase activity
GO:0008236
1902
Metallopeptidase activity
GO:0008237
3511
Exopeptidase activity
GO:0008238
2
Dipeptidyl-peptidase activity
GO:0008239
26
Tripeptidyl-peptidase activity
GO:0008240
8
Peptidyl-dipeptidase activity
GO:0008241
7
Omega peptidase activity
GO:0008242
1899
TRNA-specific adenosine deaminase activity
GO:0008251
159
Nucleotidase activity
GO:0008252
1
5'-nucleotidase activity
GO:0008253
2148
3'-nucleotidase activity
GO:0008254
730
3-oxoacid CoA-transferase activity
GO:0008260
1
Importin-alpha export receptor activity
GO:0008262
1
Pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0008263
112
Poly(U) RNA binding
GO:0008266
32
Poly-glutamine tract binding
GO:0008267
10
Zinc ion binding
GO:0008270
8260
Secondary active sulfate transmembrane transporter activity
GO:0008271
1249
Calcium, potassium:sodium antiporter activity
GO:0008273
478
Protein methyltransferase activity
GO:0008276
589
Sulfonylurea receptor activity
GO:0008281
5
Lipid binding
GO:0008289
5155
Calcium- and calmodulin-responsive adenylate cyclase activity
GO:0008294
289
3'-5'-exodeoxyribonuclease activity
GO:0008296
1
DNA binding, bending
GO:0008301
1353
Structural constituent of muscle
GO:0008307
1276
Voltage-gated anion channel activity
GO:0008308
6
Double-stranded DNA specific exodeoxyribonuclease activity
GO:0008309
4
Single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
GO:0008310
612
Double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
GO:0008311
2
7S RNA binding
GO:0008312
646
Protein prenyltransferase activity
GO:0008318
49
Protein transmembrane transporter activity
GO:0008320
53
Ral guanyl-nucleotide exchange factor activity
GO:0008321
19
Cation transmembrane transporter activity
GO:0008324
1915
Methyl-CpG binding
GO:0008327
968
Pattern recognition receptor activity
GO:0008329
854
Protein tyrosine/threonine phosphatase activity
GO:0008330
1424
High voltage-gated calcium channel activity
GO:0008331
491
Low voltage-gated calcium channel activity
GO:0008332
12
MAP kinase kinase kinase kinase activity
GO:0008349
375
RNA polymerase II carboxy-terminal domain kinase activity
GO:0008353
1512
Sialyltransferase activity
GO:0008373
1273
O-acyltransferase activity
GO:0008374
1
Acetylglucosaminyltransferase activity
GO:0008375
34
Acetylgalactosaminyltransferase activity
GO:0008376
19
Galactosyltransferase activity
GO:0008378
919
Thioredoxin peroxidase activity
GO:0008379
41
IkappaB kinase activity
GO:0008384
21
Cholesterol monooxygenase (side-chain-cleaving) activity
GO:0008386
2
Coumarin 7-hydroxylase activity
GO:0008389
3
Arachidonic acid epoxygenase activity
GO:0008392
938
Steroid hydroxylase activity
GO:0008395
1690
Sterol 12-alpha-hydroxylase activity
GO:0008397
675
Sterol 14-demethylase activity
GO:0008398
656
Retinoic acid 4-hydroxylase activity
GO:0008401
5
25-hydroxycholecalciferol-24-hydroxylase activity
GO:0008403
8
3'-5' exonuclease activity
GO:0008408
1069
5'-3' exonuclease activity
GO:0008409
1368
CoA-transferase activity
GO:0008410
1
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0008413
468
Fucosyltransferase activity
GO:0008417
3178
RNA lariat debranching enzyme activity
GO:0008419
595
CTD phosphatase activity
GO:0008420
4
Beta-glucosidase activity
GO:0008422
10
Glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0008424
28
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0008425
4
Protein kinase C inhibitor activity
GO:0008426
4
Calcium-dependent protein kinase inhibitor activity
GO:0008427
2
Ribonuclease inhibitor activity
GO:0008428
2
Phosphatidylethanolamine binding
GO:0008429
1257
Selenium binding
GO:0008430
405
Vitamin E binding
GO:0008431
353
JUN kinase binding
GO:0008432
1174
Vitamin D3 receptor activity
GO:0008434
415
Thyrotropin-releasing hormone activity
GO:0008437
1
Inositol-1,4,5-trisphosphate 3-kinase activity
GO:0008440
28
3'(2'),5'-bisphosphate nucleotidase activity
GO:0008441
730
GDP-mannose 4,6-dehydratase activity
GO:0008446
1
N-acetylglucosamine-6-phosphate deacetylase activity
GO:0008448
1
N-acetylglucosamine-6-sulfatase activity
GO:0008449
14
Alanine-glyoxylate transaminase activity
GO:0008453
2
Alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0008454
1116
Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0008455
4
Alpha-N-acetylgalactosaminidase activity
GO:0008456
4
Carnitine O-octanoyltransferase activity
GO:0008458
158
Chondroitin 6-sulfotransferase activity
GO:0008459
3
DTDP-glucose 4,6-dehydratase activity
GO:0008460
1
Glycogenin glucosyltransferase activity
GO:0008466
129
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
GO:0008467
11
Histone-arginine N-methyltransferase activity
GO:0008469
216
Isovaleryl-CoA dehydrogenase activity
GO:0008470
1362
Palmitoyl-(protein) hydrolase activity
GO:0008474
35
Procollagen-lysine 5-dioxygenase activity
GO:0008475
14
Protein-tyrosine sulfotransferase activity
GO:0008476
5
Pyridoxal kinase activity
GO:0008478
617
Queuine tRNA-ribosyltransferase activity
GO:0008479
1
Sarcosine dehydrogenase activity
GO:0008480
2
Sphinganine kinase activity
GO:0008481
2
Sulfite oxidase activity
GO:0008482
14
Transaminase activity
GO:0008483
13
Sulfuric ester hydrolase activity
GO:0008484
2013
Diphosphoinositol-polyphosphate diphosphatase activity
GO:0008486
52
Gamma-glutamyl carboxylase activity
GO:0008488
1369
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0008489
44
Translation activator activity
GO:0008494
518
Protoheme IX farnesyltransferase activity
GO:0008495
2
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO:0008499
205
Melatonin receptor activity
GO:0008502
7
Benzodiazepine receptor activity
GO:0008503
69
Monoamine transmembrane transporter activity
GO:0008504
1053
Sodium:iodide symporter activity
GO:0008507
923
Bile acid:sodium symporter activity
GO:0008508
14
Anion transmembrane transporter activity
GO:0008509
533
Sodium:bicarbonate symporter activity
GO:0008510
800
Sodium:potassium:chloride symporter activity
GO:0008511
578
Secondary active organic cation transmembrane transporter activity
GO:0008513
3
Organic anion transmembrane transporter activity
GO:0008514
47
Folic acid transporter activity
GO:0008517
1097
Ammonium transmembrane transporter activity
GO:0008519
1310
L-ascorbate:sodium symporter activity
GO:0008520
24
Sodium-dependent multivitamin transmembrane transporter activity
GO:0008523
21
Phosphatidylcholine transporter activity
GO:0008525
6
Phosphatidylinositol transporter activity
GO:0008526
41
Taste receptor activity
GO:0008527
631
G-protein coupled peptide receptor activity
GO:0008528
690
Riboflavin kinase activity
GO:0008531
220
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
GO:0008532
1
Oxidized purine base lesion DNA N-glycosylase activity
GO:0008534
10
Ran GTPase binding
GO:0008536
1355
JUN kinase kinase activity
GO:0008545
11
Hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0008553
352
Sodium-exporting ATPase activity, phosphorylative mechanism
GO:0008554
3
Chloride-transporting ATPase activity
GO:0008555
1161
Xenobiotic-transporting ATPase activity
GO:0008559
7
Protein transporter activity
GO:0008565
4699
Microtubule-severing ATPase activity
GO:0008568
1238
Minus-end-directed microtubule motor activity
GO:0008569
8
Plus-end-directed microtubule motor activity
GO:0008574
3848
JUN kinase phosphatase activity
GO:0008579
1424
Protein phosphatase type 1 regulator activity
GO:0008599
594
Protein phosphatase type 2A regulator activity
GO:0008601
1041
CAMP-dependent protein kinase regulator activity
GO:0008603
30
Phosphorylase kinase regulator activity
GO:0008607
540
Alkylglycerone-phosphate synthase activity
GO:0008609
14
Small protein activating enzyme activity
GO:0008641
11
RRNA (uridine-2'-O-)-methyltransferase activity
GO:0008650
90
Cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
2448
2'-phosphotransferase activity
GO:0008665
1
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
GO:0008667
133
2,4-dienoyl-CoA reductase (NADPH) activity
GO:0008670
475
3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0008689
4
Methionine synthase activity
GO:0008705
586
D-serine ammonia-lyase activity
GO:0008721
1
L-allo-threonine aldolase activity
GO:0008732
9
N-acetylmuramoyl-L-alanine amidase activity
GO:0008745
4
NAD(P)+ transhydrogenase activity
GO:0008746
5
N-acetylneuraminate lyase activity
GO:0008747
3
NAD(P)+ transhydrogenase (AB-specific) activity
GO:0008750
5
NADPH dehydrogenase (quinone) activity
GO:0008753
2
S-adenosylmethionine-dependent methyltransferase activity
GO:0008757
1621
UDP-N-acetylglucosamine 2-epimerase activity
GO:0008761
1948
UDP-N-acetylmuramate dehydrogenase activity
GO:0008762
272
UDP-sugar diphosphatase activity
GO:0008768
1
Agmatinase activity
GO:0008783
1903
Arsenate reductase (glutaredoxin) activity
GO:0008794
1
Beta-aspartyl-peptidase activity
GO:0008798
77
Betaine-aldehyde dehydrogenase activity
GO:0008802
519
Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
GO:0008803
4
Choline dehydrogenase activity
GO:0008812
396
Cob(I)yrinic acid a,c-diamide adenosyltransferase activity
GO:0008817
426
Crossover junction endodeoxyribonuclease activity
GO:0008821
366
Cupric reductase activity
GO:0008823
1207
DTDP-4-dehydrorhamnose reductase activity
GO:0008831
2
Endochitinase activity
GO:0008843
2
Exodeoxyribonuclease III activity
GO:0008853
6
Exoribonuclease II activity
GO:0008859
2
Fructokinase activity
GO:0008865
274
Glycerate kinase activity
GO:0008887
9
Glycerophosphodiester phosphodiesterase activity
GO:0008889
2035
Glycine C-acetyltransferase activity
GO:0008890
340
Glycolate oxidase activity
GO:0008891
2
Guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
GO:0008894
3
Homocysteine S-methyltransferase activity
GO:0008898
1562
Hydrogen:potassium-exchanging ATPase activity
GO:0008900
10
Hydroxypyruvate isomerase activity
GO:0008903
1
Integrase activity
GO:0008907
5
Inositol monophosphate 1-phosphatase activity
GO:0008934
969
Nitric oxide dioxygenase activity
GO:0008941
4
Oxaloacetate decarboxylase activity
GO:0008948
933
Phosphatidylglycerophosphatase activity
GO:0008962
3
Phospho-N-acetylmuramoyl-pentapeptide-transferase activity
GO:0008963
1
Phosphohistidine phosphatase activity
GO:0008969
5
Phosphatidylcholine 1-acylhydrolase activity
GO:0008970
6
Phosphopentomutase activity
GO:0008973
2
Ribonuclease E activity
GO:0008995
1
Selenocysteine lyase activity
GO:0009000
1
DNA-methyltransferase activity
GO:0009008
64
Succinate-semialdehyde dehydrogenase [NAD(P)+] activity
GO:0009013
708
Uridylate kinase activity
GO:0009041
2
Electron carrier activity
GO:0009055
3732
Biotin binding
GO:0009374
846
Four-way junction helicase activity
GO:0009378
207
N-acylmannosamine kinase activity
GO:0009384
1948
Low affinity phosphate transmembrane transporter activity
GO:0009673
3
Photoreceptor activity
GO:0009881
24
Blue light photoreceptor activity
GO:0009882
10
Sterol 5-alpha reductase activity
GO:0009917
3
Fatty acid elongase activity
GO:0009922
10
Pseudouridine synthase activity
GO:0009982
60
FMN binding
GO:0010181
2269
Phosphatidylinositol-5-phosphate binding
GO:0010314
2093
Double-stranded methylated DNA binding
GO:0010385
18
Methyl-CpNpG binding
GO:0010428
10
Nerve growth factor receptor activity
GO:0010465
5
H3 histone acetyltransferase activity
GO:0010484
766
H4 histone acetyltransferase activity
GO:0010485
1357
Telomerase inhibitor activity
GO:0010521
4
Metalloenzyme activator activity
GO:0010577
4
Serum response element binding
GO:0010736
10
Recombination hotspot binding
GO:0010844
2
Adenylate cyclase inhibitor activity
GO:0010855
6
Thyroid hormone receptor activator activity
GO:0010861
2
Anaphase-promoting complex binding
GO:0010997
2006
[heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0015016
680
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
GO:0015018
4
Heparan-alpha-glucosaminide N-acetyltransferase activity
GO:0015019
7
Glucuronosyltransferase activity
GO:0015020
441
Coreceptor activity
GO:0015026
565
Protein disulfide oxidoreductase activity
GO:0015035
469
Disulfide oxidoreductase activity
GO:0015036
390
Glutathione disulfide oxidoreductase activity
GO:0015038
4
NADPH-adrenodoxin reductase activity
GO:0015039
2
Beta3-adrenergic receptor activity
GO:0015052
13
Gastrin receptor activity
GO:0015054
2
Secretin receptor activity
GO:0015055
3
Corticotrophin-releasing factor receptor activity
GO:0015056
27
Thrombin receptor activity
GO:0015057
2136
Amidinotransferase activity
GO:0015067
1
Glycine amidinotransferase activity
GO:0015068
1
Ion transmembrane transporter activity
GO:0015075
14
Monovalent inorganic cation transmembrane transporter activity
GO:0015077
1438
Hydrogen ion transmembrane transporter activity
GO:0015078
2849
Potassium ion transmembrane transporter activity
GO:0015079
1704
Sodium ion transmembrane transporter activity
GO:0015081
18
Calcium ion transmembrane transporter activity
GO:0015085
614
Cadmium ion transmembrane transporter activity
GO:0015086
591
Cobalt ion transmembrane transporter activity
GO:0015087
591
Copper uptake transmembrane transporter activity
GO:0015088
1046
Ferrous iron transmembrane transporter activity
GO:0015093
648
Lead ion transmembrane transporter activity
GO:0015094
591
Magnesium ion transmembrane transporter activity
GO:0015095
1338
Nickel cation transmembrane transporter activity
GO:0015099
591
Vanadium ion transmembrane transporter activity
GO:0015100
591
Organic cation transmembrane transporter activity
GO:0015101
13
Bicarbonate transmembrane transporter activity
GO:0015106
537
Chloride transmembrane transporter activity
GO:0015108
1164
Iodide transmembrane transporter activity
GO:0015111
1752
Nitrate transmembrane transporter activity
GO:0015112
787
Sulfate transmembrane transporter activity
GO:0015116
1249
Bile acid transmembrane transporter activity
GO:0015125
8
Canalicular bile acid transmembrane transporter activity
GO:0015126
3
Lactate transmembrane transporter activity
GO:0015129
803
Mevalonate transmembrane transporter activity
GO:0015130
5
Sialic acid transmembrane transporter activity
GO:0015136
794
Citrate transmembrane transporter activity
GO:0015137
14
Succinate transmembrane transporter activity
GO:0015141
8
Urate transmembrane transporter activity
GO:0015143
3
Hexose transmembrane transporter activity
GO:0015149
2
Glucose-6-phosphate transmembrane transporter activity
GO:0015152
4
Polyol transmembrane transporter activity
GO:0015166
2
Glycerol transmembrane transporter activity
GO:0015168
12
Amino acid transmembrane transporter activity
GO:0015171
2329
Basic amino acid transmembrane transporter activity
GO:0015174
787
Neutral amino acid transmembrane transporter activity
GO:0015175
253
L-amino acid transmembrane transporter activity
GO:0015179
1598
L-alanine transmembrane transporter activity
GO:0015180
1081
Arginine transmembrane transporter activity
GO:0015181
608
L-asparagine transmembrane transporter activity
GO:0015182
11
L-aspartate transmembrane transporter activity
GO:0015183
224
L-cystine transmembrane transporter activity
GO:0015184
617
L-glutamine transmembrane transporter activity
GO:0015186
49
Glycine transmembrane transporter activity
GO:0015187
1068
L-lysine transmembrane transporter activity
GO:0015189
784
L-proline transmembrane transporter activity
GO:0015193
1070
L-serine transmembrane transporter activity
GO:0015194
838
L-threonine transmembrane transporter activity
GO:0015195
12
Peptide transporter activity
GO:0015197
65
Oligopeptide transporter activity
GO:0015198
725
Urea transmembrane transporter activity
GO:0015204
1541
Nucleobase transmembrane transporter activity
GO:0015205
24
Adenine transmembrane transporter activity
GO:0015207
315
Purine nucleoside transmembrane transporter activity
GO:0015211
760
Purine nucleotide transmembrane transporter activity
GO:0015216
4
ADP transmembrane transporter activity
GO:0015217
2
Choline transmembrane transporter activity
GO:0015220
3
Serotonin transmembrane transporter activity
GO:0015222
1037
Carnitine transporter activity
GO:0015226
6
Acyl carnitine transporter activity
GO:0015227
1
Coenzyme A transmembrane transporter activity
GO:0015228
2
L-ascorbic acid transporter activity
GO:0015229
24
FAD transmembrane transporter activity
GO:0015230
2
Heme transporter activity
GO:0015232
897
Drug transmembrane transporter activity
GO:0015238
9
Fatty acid transporter activity
GO:0015245
1
Sterol transporter activity
GO:0015248
5
Water channel activity
GO:0015250
964
Hydrogen ion channel activity
GO:0015252
12
Glycerol channel activity
GO:0015254
814
Urea channel activity
GO:0015265
441
Protein channel activity
GO:0015266
10
Channel activity
GO:0015267
757
Calcium-activated potassium channel activity
GO:0015269
64
Outward rectifier potassium channel activity
GO:0015271
13
ATP-activated inward rectifier potassium channel activity
GO:0015272
859
Ligand-gated ion channel activity
GO:0015276
1671
Kainate selective glutamate receptor activity
GO:0015277
34
Calcium-release channel activity
GO:0015278
974
Store-operated calcium channel activity
GO:0015279
34
Ligand-gated sodium channel activity
GO:0015280
112
Porin activity
GO:0015288
15
Symporter activity
GO:0015293
1167
Solute:hydrogen symporter activity
GO:0015295
591
Antiporter activity
GO:0015297
1048
Solute:hydrogen antiporter activity
GO:0015299
21
Anion:anion antiporter activity
GO:0015301
810
Sodium:inorganic phosphate symporter activity
GO:0015319
2
Phosphate ion carrier activity
GO:0015320
1
Sodium-dependent phosphate transmembrane transporter activity
GO:0015321
104
Cystine:glutamate antiporter activity
GO:0015327
1055
Peptide:hydrogen symporter activity
GO:0015333
1512
High affinity oligopeptide transporter activity
GO:0015334
787
Sodium-independent organic anion transmembrane transporter activity
GO:0015347
441
Methotrexate transporter activity
GO:0015350
198
Secondary active monocarboxylate transmembrane transporter activity
GO:0015355
803
Low affinity sodium:dicarboxylate symporter activity
GO:0015361
5
High affinity sodium:dicarboxylate symporter activity
GO:0015362
8
Glycine:sodium symporter activity
GO:0015375
9
Cation:chloride symporter activity
GO:0015377
865
Sodium:chloride symporter activity
GO:0015378
388
Potassium:chloride symporter activity
GO:0015379
1689
Sodium:sulfate symporter activity
GO:0015382
350
Sodium:hydrogen antiporter activity
GO:0015385
82
Potassium:hydrogen antiporter activity
GO:0015386
10
Pyrimidine- and adenine-specific:sodium symporter activity
GO:0015389
6
Purine-specific nucleoside:sodium symporter activity
GO:0015390
6
Thiamine uptake transmembrane transporter activity
GO:0015403
662
Manganese-transporting ATPase activity
GO:0015410
5
Bile acid-exporting ATPase activity
GO:0015432
3
Peptide antigen-transporting ATPase activity
GO:0015433
1379
Heme-transporting ATPase activity
GO:0015439
7
Peptide-transporting ATPase activity
GO:0015440
5
P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0015450
712
Potassium channel regulator activity
GO:0015459
2351
Acetylcholine receptor activity
GO:0015464
1906
G-protein activated inward rectifier potassium channel activity
GO:0015467
1654
Cholesterol binding
GO:0015485
2574
Gamma-aminobutyric acid:hydrogen symporter activity
GO:0015495
1
Formate transmembrane transporter activity
GO:0015499
1
Efflux transmembrane transporter activity
GO:0015562
1388
DNA translocase activity
GO:0015616
610
Tubulin binding
GO:0015631
3064
Zinc transporting ATPase activity
GO:0015633
14
Short-chain fatty acid uptake transporter activity
GO:0015636
425
Toxin binding
GO:0015643
2057
Fatty acid ligase activity
GO:0015645
3
Quaternary ammonium group transmembrane transporter activity
GO:0015651
8
Formate uptake transmembrane transporter activity
GO:0015659
1
Formate efflux transmembrane transporter activity
GO:0015660
1
Mannosidase activity
GO:0015923
606
Phospholipase activator activity
GO:0016004
1883
Phospholipase A2 activator activity
GO:0016005
5
Morphogen activity
GO:0016015
938
Cyclosporin A binding
GO:0016018
844
Peptidoglycan receptor activity
GO:0016019
5
Translation release factor activity, codon specific
GO:0016149
10
Nickel cation binding
GO:0016151
593
Urocanate hydratase activity
GO:0016153
6
Lipoxygenase activity
GO:0016165
68
Glial cell-derived neurotrophic factor receptor activity
GO:0016167
31
NAD(P)H oxidase activity
GO:0016174
1095
Superoxide-generating NADPH oxidase activity
GO:0016175
343
Superoxide-generating NADPH oxidase activator activity
GO:0016176
13
Catechol O-methyltransferase activity
GO:0016206
1487
AMP binding
GO:0016208
1187
Antioxidant activity
GO:0016209
685
Kynurenine-oxoglutarate transaminase activity
GO:0016212
7
Steroid dehydrogenase activity
GO:0016229
4
Sphingomyelin phosphodiesterase activator activity
GO:0016230
3
Beta-N-acetylglucosaminidase activity
GO:0016231
3
HNK-1 sulfotransferase activity
GO:0016232
2
Channel regulator activity
GO:0016247
4
Channel inhibitor activity
GO:0016248
4
N-sulfoglucosamine sulfohydrolase activity
GO:0016250
3
Protein N-acetylglucosaminyltransferase activity
GO:0016262
521
Protein-arginine N-methyltransferase activity
GO:0016274
18
[cytochrome c]-arginine N-methyltransferase activity
GO:0016275
1
[myelin basic protein]-arginine N-methyltransferase activity
GO:0016277
194
Protein-lysine N-methyltransferase activity
GO:0016279
1136
Small conductance calcium-activated potassium channel activity
GO:0016286
1465
Palmitoyl-CoA hydrolase activity
GO:0016290
1102
Myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0016295
675
Palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296
675
Lipase activity
GO:0016298
18
TRNA (uracil) methyltransferase activity
GO:0016300
5
Kinase activity
GO:0016301
2653
1-phosphatidylinositol-3-kinase activity
GO:0016303
2954
Phosphatidylinositol phosphate kinase activity
GO:0016307
20
1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016308
511
1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0016309
11
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016314
7
Phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0016316
9
Activin receptor activity, type I
GO:0016361
484
Activin receptor activity, type II
GO:0016362
858
Palmitoyl-CoA oxidase activity
GO:0016401
1602
Pristanoyl-CoA oxidase activity
GO:0016402
5
Dimethylargininase activity
GO:0016403
2
15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016404
90
Acetyltransferase activity
GO:0016407
723
Palmitoyltransferase activity
GO:0016409
1993
N-acyltransferase activity
GO:0016410
3
MRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0016422
6
TRNA (cytosine) methyltransferase activity
GO:0016427
1123
TRNA (cytosine-5-)-methyltransferase activity
GO:0016428
3
Pyrophosphatase activity
GO:0016462
29
Oxidoreductase activity
GO:0016491
5402
G-protein coupled neurotensin receptor activity
GO:0016492
11
C-C chemokine receptor activity
GO:0016493
1608
C-X-C chemokine receptor activity
GO:0016494
1173
C-X3-C chemokine receptor activity
GO:0016495
3
Substance P receptor activity
GO:0016496
10
Substance K receptor activity
GO:0016497
9
Protein-hormone receptor activity
GO:0016500
4
Pheromone receptor activity
GO:0016503
2
Peptidase activator activity
GO:0016504
43
Apoptotic protease activator activity
GO:0016505
67
Long-chain-enoyl-CoA hydratase activity
GO:0016508
6
Long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016509
6
Interleukin-13 receptor activity
GO:0016515
419
Interleukin-12 receptor activity
GO:0016517
937
Gastric inhibitory peptide receptor activity
GO:0016519
1
Growth hormone-releasing hormone receptor activity
GO:0016520
12
Pituitary adenylate cyclase activating polypeptide activity
GO:0016521
4
Latrotoxin receptor activity
GO:0016524
8
Superoxide dismutase copper chaperone activity
GO:0016532
438
Cyclin-dependent protein kinase 5 activator activity
GO:0016534
4
Cyclin-dependent protein kinase regulator activity
GO:0016538
380
Glycine binding
GO:0016594
1898
Glutamate binding
GO:0016595
1984
Amino acid binding
GO:0016597
1872
Glutaminyl-peptide cyclotransferase activity
GO:0016603
1338
Growth hormone-releasing hormone activity
GO:0016608
2
Oxidoreductase activity, acting on CH-OH group of donors
GO:0016614
396
Malate dehydrogenase activity
GO:0016615
5
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016616
745
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016620
1774
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0016624
229
Oxidoreductase activity, acting on the CH-CH group of donors
GO:0016627
2085
Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0016628
149
Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0016641
6
Oxidoreductase activity, acting on NADH or NADPH
GO:0016651
1219
Oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
GO:0016653
3
Oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
GO:0016655
9
Oxidoreductase activity, acting on a sulfur group of donors
GO:0016667
8
Oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor
GO:0016668
1144
Oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
GO:0016670
1164
Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0016671
94
Oxidoreductase activity, acting on diphenols and related substances as donors
GO:0016679
1
Oxidoreductase activity, acting on peroxide as acceptor
GO:0016684
4
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016702
183
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016705
3633
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0016706
2249
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
GO:0016709
940
Flavonoid 3'-monooxygenase activity
GO:0016711
1
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0016712
2318
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0016714
9
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0016715
18
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0016716
1
Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0016717
2
Oxidoreductase activity, oxidizing metal ions
GO:0016722
4
Transferase activity
GO:0016740
2968
Hydroxymethyl-, formyl- and related transferase activity
GO:0016742
1634
Carboxyl- or carbamoyltransferase activity
GO:0016743
6
Transferase activity, transferring acyl groups
GO:0016746
3457
Transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016747
1092
Transferase activity, transferring glycosyl groups
GO:0016757
3376
Transferase activity, transferring hexosyl groups
GO:0016758
1802
Transferase activity, transferring pentosyl groups
GO:0016763
154
Spermine synthase activity
GO:0016768
2
Transferase activity, transferring phosphorus-containing groups
GO:0016772
1239
Phosphotransferase activity, alcohol group as acceptor
GO:0016773
3554
Nucleotidyltransferase activity
GO:0016779
1187
Phosphotransferase activity, for other substituted phosphate groups
GO:0016780
522
Sulfurtransferase activity
GO:0016783
7
3-mercaptopyruvate sulfurtransferase activity
GO:0016784
1
Transferase activity, transferring selenium-containing groups
GO:0016785
4
Hydrolase activity
GO:0016787
5016
Hydrolase activity, acting on ester bonds
GO:0016788
1021
Thiolester hydrolase activity
GO:0016790
37
Phosphatase activity
GO:0016791
2852
Hydrolase activity, acting on glycosyl bonds
GO:0016798
1167
Hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016799
762
Dipeptidase activity
GO:0016805
262
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016810
20
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0016811
316
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0016812
15
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0016813
2
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0016814
1810
Hydrolase activity, acting on acid anhydrides
GO:0016817
502
Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016818
211
Hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016820
8
Lyase activity
GO:0016829
1710
Carboxy-lyase activity
GO:0016831
1381
Ammonia-lyase activity
GO:0016841
4
Carbon-sulfur lyase activity
GO:0016846
301
Phosphorus-oxygen lyase activity
GO:0016849
75
Isomerase activity
GO:0016853
1882
Racemase and epimerase activity
GO:0016854
1
Racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0016857
53
Intramolecular transferase activity
GO:0016866
1415
Intramolecular transferase activity, phosphotransferases
GO:0016868
10
Ligase activity
GO:0016874
5904
Acid-thiol ligase activity
GO:0016878
6
Acid-amino acid ligase activity
GO:0016881
2895
Carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0016884
782
ATPase activity
GO:0016887
5098
Endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0016888
1424
Endoribonuclease activity, producing 5'-phosphomonoesters
GO:0016891
5
Exoribonuclease activity, producing 5'-phosphomonoesters
GO:0016896
1240
Oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0016903
243
G-protein coupled acetylcholine receptor activity
GO:0016907
142
GABA receptor activity
GO:0016917
5
Retinal binding
GO:0016918
555
Pyroglutamyl-peptidase activity
GO:0016920
2040
Ligand-dependent nuclear receptor binding
GO:0016922
1229
SUMO-specific protease activity
GO:0016929
22
Extracellular-glycine-gated ion channel activity
GO:0016933
2
Extracellular-glycine-gated chloride channel activity
GO:0016934
18
Galactoside binding
GO:0016936
3
Natriuretic peptide receptor activity
GO:0016941
5
Flavin-linked sulfhydryl oxidase activity
GO:0016971
7
Thiol oxidase activity
GO:0016972
4
Lipoate synthase activity
GO:0016992
735
Activin-activated receptor activity
GO:0017002
14
3'-tyrosyl-DNA phosphodiesterase activity
GO:0017005
216
Ras GTPase binding
GO:0017016
641
MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0017017
195
Myosin phosphatase regulator activity
GO:0017020
4
Myosin binding
GO:0017022
2755
TBP-class protein binding
GO:0017025
1606
Rap guanyl-nucleotide exchange factor activity
GO:0017034
619
Ceramidase activity
GO:0017040
14
Corticotropin-releasing hormone activity
GO:0017045
2
Peptide hormone binding
GO:0017046
1815
Rho GTPase binding
GO:0017048
716
GTP-Rho binding
GO:0017049
2003
D-erythro-sphingosine kinase activity
GO:0017050
2
Structural constituent of nuclear pore
GO:0017056
759
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0017060
727
S-methyl-5-thioadenosine phosphorylase activity
GO:0017061
562
Single-strand selective uracil DNA N-glycosylase activity
GO:0017065
681
SnRNA binding
GO:0017069
4
U6 snRNA binding
GO:0017070
309
Syntaxin-1 binding
GO:0017075
1281
Purine nucleotide binding
GO:0017076
4
Oxidative phosphorylation uncoupler activity
GO:0017077
3
Sodium channel regulator activity
GO:0017080
3311
Chloride channel regulator activity
GO:0017081
1482
Glycolipid transporter activity
GO:0017089
17
AU-rich element binding
GO:0017091
74
Heparan sulfate 6-O-sulfotransferase activity
GO:0017095
12
Sulfonylurea receptor binding
GO:0017098
2
5'-flap endonuclease activity
GO:0017108
16
Nucleoside-diphosphatase activity
GO:0017110
873
Nucleoside-triphosphatase activity
GO:0017111
875
Rab guanyl-nucleotide exchange factor activity
GO:0017112
2030
Dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017113
19
Single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0017116
2
SH3 domain binding
GO:0017124
4236
Deoxycytidyl transferase activity
GO:0017125
4
Cholesterol transporter activity
GO:0017127
30
Phospholipid scramblase activity
GO:0017128
682
Triglyceride binding
GO:0017129
4
Poly(C) RNA binding
GO:0017130
1
Fibroblast growth factor binding
GO:0017134
1556
NAD-dependent histone deacetylase activity
GO:0017136
6
Rab GTPase binding
GO:0017137
4321
Wnt-protein binding
GO:0017147
2135
TRNA dihydrouridine synthase activity
GO:0017150
1
DEAD/H-box RNA helicase binding
GO:0017151
6
Sodium:dicarboxylate symporter activity
GO:0017153
252
Semaphorin receptor activity
GO:0017154
78
Pantetheine hydrolase activity
GO:0017159
7
Ral GTPase binding
GO:0017160
5
Aryl hydrocarbon receptor binding
GO:0017162
82
Vinculin binding
GO:0017166
485
5-oxoprolinase (ATP-hydrolyzing) activity
GO:0017168
2
Serine hydrolase activity
GO:0017171
15
Phosphatidylinositol N-acetylglucosaminyltransferase activity
GO:0017176
3
Aspartate N-acetyltransferase activity
GO:0017188
3
Histone-lysine N-methyltransferase activity
GO:0018024
1206
Threonine racemase activity
GO:0018114
1
Biotin-protein ligase activity
GO:0018271
523
Alcohol dehydrogenase [NAD(P)+] activity
GO:0018455
3
Malonate-semialdehyde dehydrogenase (acetylating) activity
GO:0018478
1616
Benzaldehyde dehydrogenase (NAD+) activity
GO:0018479
4
Fluorene oxygenase activity
GO:0018585
4
(S)-limonene 6-monooxygenase activity
GO:0018675
5
(S)-limonene 7-monooxygenase activity
GO:0018676
5
Alkane 1-monooxygenase activity
GO:0018685
9
3,4-dihydrocoumarin hydrolase activity
GO:0018733
1
Acetylpyruvate hydrolase activity
GO:0018773
700
Guanyl nucleotide binding
GO:0019001
751
GMP binding
GO:0019002
449
GDP binding
GO:0019003
5038
DNA N-glycosylase activity
GO:0019104
688
Benzaldehyde dehydrogenase activity
GO:0019115
9
Phenanthrene-9,10-epoxide hydrolase activity
GO:0019119
370
Deoxyhypusine monooxygenase activity
GO:0019135
1
ADP-sugar diphosphatase activity
GO:0019144
19
Aminobutyraldehyde dehydrogenase activity
GO:0019145
2
Protein-disulfide reductase (glutathione) activity
GO:0019153
1
Mannokinase activity
GO:0019158
274
Trans-2-enoyl-CoA reductase (NADPH) activity
GO:0019166
738
Glyoxalase III activity
GO:0019172
1
Nucleotide kinase activity
GO:0019201
2
Carbohydrate phosphatase activity
GO:0019203
2
Nucleobase-containing compound kinase activity
GO:0019205
788
Nucleoside kinase activity
GO:0019206
123
Kinase regulator activity
GO:0019207
2
Phosphatase regulator activity
GO:0019208
32
Kinase activator activity
GO:0019209
14
Kinase inhibitor activity
GO:0019210
185
Phosphatase activator activity
GO:0019211
110
Phosphatase inhibitor activity
GO:0019212
23
Deacetylase activity
GO:0019213
1289
Intermediate filament binding
GO:0019215
440
Centromeric DNA binding
GO:0019237
878
Deaminase activity
GO:0019239
1104
Oxalate transmembrane transporter activity
GO:0019531
1
Toxin transporter activity
GO:0019534
15
Protein-cysteine S-palmitoleyltransferase activity
GO:0019706
2004
IgE receptor activity
GO:0019767
685
IgG receptor activity
GO:0019770
4
Atg8 ligase activity
GO:0019776
2
Atg12 ligase activity
GO:0019777
717
APG12 activating enzyme activity
GO:0019778
4
APG8 activating enzyme activity
GO:0019779
4
NEDD8-specific protease activity
GO:0019784
14
ISG15-specific protease activity
GO:0019785
2
Small conjugating protein ligase activity
GO:0019787
2406
NEDD8 ligase activity
GO:0019788
769
SUMO ligase activity
GO:0019789
14
Procollagen-proline 3-dioxygenase activity
GO:0019797
58
Aspartoacylase activity
GO:0019807
1
Polyamine binding
GO:0019808
3
Spermidine binding
GO:0019809
1
Cocaine binding
GO:0019811
1036
Oxygen binding
GO:0019825
2017
Oxygen sensor activity
GO:0019826
350
Aspartic-type endopeptidase inhibitor activity
GO:0019828
14
Cation-transporting ATPase activity
GO:0019829
1702
Phospholipase A2 inhibitor activity
GO:0019834
8
Growth factor binding
GO:0019838
2786
Isoprenoid binding
GO:0019840
2
Retinol binding
GO:0019841
556
Vitamin binding
GO:0019842
2
RRNA binding
GO:0019843
1829
Calcium channel inhibitor activity
GO:0019855
33
IgA binding
GO:0019862
1302
IgE binding
GO:0019863
685
IgG binding
GO:0019864
471
Immunoglobulin binding
GO:0019865
10
Chloride channel inhibitor activity
GO:0019869
633
Potassium channel inhibitor activity
GO:0019870
523
Sodium channel inhibitor activity
GO:0019871
513
Protein kinase regulator activity
GO:0019887
23
Protein phosphatase regulator activity
GO:0019888
10
Kinesin binding
GO:0019894
3381
Enzyme binding
GO:0019899
6311
Kinase binding
GO:0019900
3845
Protein kinase binding
GO:0019901
6010
Phosphatase binding
GO:0019902
2531
Protein phosphatase binding
GO:0019903
3099
Protein domain specific binding
GO:0019904
5613
Syntaxin binding
GO:0019905
3417
Structural constituent of myelin sheath
GO:0019911
1191
Cyclin-dependent protein kinase activating kinase activity
GO:0019912
5
SUMO activating enzyme activity
GO:0019948
11
Cytokine binding
GO:0019955
1517
C-C chemokine binding
GO:0019957
889
Interleukin-8 binding
GO:0019959
287
Type I interferon binding
GO:0019962
604
Interferon-gamma binding
GO:0019964
5
Interleukin-1 binding
GO:0019966
744
Interleukin-11 binding
GO:0019970
6
Interleukin-2 binding
GO:0019976
237
Interleukin-6 binding
GO:0019981
1362
Diacylglycerol binding
GO:0019992
1313
Heme binding
GO:0020037
4821
Transmitter-gated ion channel activity
GO:0022824
20
Wide pore channel activity
GO:0022829
6
Leak channel activity
GO:0022840
2
Potassium ion leak channel activity
GO:0022841
159
Voltage-gated cation channel activity
GO:0022843
214
Acetylcholine-gated cation channel activity
GO:0022848
520
GABA-gated chloride ion channel activity
GO:0022851
5
Transmembrane transporter activity
GO:0022857
2679
Transmembrane electron transfer carrier
GO:0022865
428
Inorganic cation transmembrane transporter activity
GO:0022890
652
Substrate-specific transmembrane transporter activity
GO:0022891
387
Intermediate conductance calcium-activated potassium channel activity
GO:0022894
5
MHC class II protein complex binding
GO:0023026
987
MHC class Ib protein binding
GO:0023029
29
Extracellular matrix structural constituent conferring tensile strength
GO:0030020
34
Extracellular matrix constituent conferring elasticity
GO:0030023
14
L-malate dehydrogenase activity
GO:0030060
2
HLA-A specific inhibitory MHC class I receptor activity
GO:0030107
567
HLA-A specific activating MHC class I receptor activity
GO:0030108
2
HLA-B specific inhibitory MHC class I receptor activity
GO:0030109
568
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
GO:0030144
2
Manganese ion binding
GO:0030145
4095
Molybdenum ion binding
GO:0030151
23
Benzodiazepine receptor binding
GO:0030156
19
Protein xylosyltransferase activity
GO:0030158
22
Receptor signaling complex scaffold activity
GO:0030159
2114
GKAP/Homer scaffold activity
GO:0030160
24
PDZ domain binding
GO:0030165
4629
Low-density lipoprotein particle binding
GO:0030169
1302
Pyridoxal phosphate binding
GO:0030170
3486
Voltage-gated proton channel activity
GO:0030171
1
Troponin C binding
GO:0030172
3
Nitric oxide transmembrane transporter activity
GO:0030184
11
Extracellular matrix constituent, lubricant activity
GO:0030197
14
Semaphorin receptor binding
GO:0030215
1053
Very-low-density lipoprotein particle receptor activity
GO:0030229
1051
Deoxynucleotide transmembrane transporter activity
GO:0030233
1
Enzyme regulator activity
GO:0030234
1566
Nitric-oxide synthase regulator activity
GO:0030235
28
Carbohydrate binding
GO:0030246
4767
Polysaccharide binding
GO:0030247
1330
Guanylate cyclase activator activity
GO:0030250
3
Guanylate cyclase inhibitor activity
GO:0030251
4
Melanin-concentrating hormone receptor activity
GO:0030273
3
LIM domain binding
GO:0030274
433
LRR domain binding
GO:0030275
472
Clathrin binding
GO:0030276
1140
Structural constituent of epidermis
GO:0030280
22
Estrogen receptor activity
GO:0030284
496
Protein serine/threonine kinase inhibitor activity
GO:0030291
974
Protein tyrosine kinase inhibitor activity
GO:0030292
707
Protein kinase activator activity
GO:0030295
1478
Protein tyrosine kinase activator activity
GO:0030296
1539
Transmembrane receptor protein tyrosine kinase activator activity
GO:0030297
349
Receptor signaling protein tyrosine kinase activator activity
GO:0030298
1121
Heparanase activity
GO:0030305
1116
ADP-ribosylation factor binding
GO:0030306
1530
Estrogen receptor binding
GO:0030331
948
Cyclin binding
GO:0030332
1606
DNA polymerase processivity factor activity
GO:0030337
1
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
GO:0030342
8
Vitamin D3 25-hydroxylase activity
GO:0030343
375
Structural constituent of tooth enamel
GO:0030345
654
Protein phosphatase 2B binding
GO:0030346
58
Syntaxin-3 binding
GO:0030348
3
Iron-responsive element binding
GO:0030350
1061
Protein phosphatase type 4 regulator activity
GO:0030362
5
Interleukin-17 receptor activity
GO:0030368
2098
ICAM-3 receptor activity
GO:0030369
507
Translation repressor activity
GO:0030371
15
High molecular weight B cell growth factor receptor binding
GO:0030372
12
Ligand-dependent nuclear receptor transcription coactivator activity
GO:0030374
3132
Thyroid hormone receptor coactivator activity
GO:0030375
17
U-plasminogen activator receptor activity
GO:0030377
135
Serine racemase activity
GO:0030378
1
Neurotensin receptor activity, non-G-protein coupled
GO:0030379
5
Interleukin-17E receptor binding
GO:0030380
2
Lactose binding
GO:0030395
36
Glutamate formimidoyltransferase activity
GO:0030409
4
Formimidoyltetrahydrofolate cyclodeaminase activity
GO:0030412
4
Peptidase inhibitor activity
GO:0030414
563
Hemoglobin binding
GO:0030492
1
Ankyrin binding
GO:0030506
1959
Spectrin binding
GO:0030507
2802
SnoRNA binding
GO:0030515
687
SnoRNP binding
GO:0030519
1
Hsp70 protein binding
GO:0030544
2707
Receptor activator activity
GO:0030546
37
Acetylcholine receptor regulator activity
GO:0030548
6
Acetylcholine receptor activator activity
GO:0030549
1
Cyclic nucleotide binding
GO:0030551
161
CAMP binding
GO:0030552
1929
CGMP binding
GO:0030553
1830
Adenyl nucleotide binding
GO:0030554
1866
Transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0030616
562
Transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0030617
8
Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0030618
1807
U1 snRNA binding
GO:0030619
5
U2 snRNA binding
GO:0030620
7
U4 snRNA binding
GO:0030621
308
U6atac snRNA binding
GO:0030624
3
Pre-mRNA 3'-splice site binding
GO:0030628
735
Protein binding, bridging
GO:0030674
3075
Rac GTPase activator activity
GO:0030675
70
Rac guanyl-nucleotide exchange factor activity
GO:0030676
805
GTPase regulator activity
GO:0030695
749
Guanidinoacetate N-methyltransferase activity
GO:0030731
526
GTP-dependent protein binding
GO:0030742
2146
Amine N-methyltransferase activity
GO:0030748
1026
Arsenite methyltransferase activity
GO:0030791
1323
Methylarsonite methyltransferase activity
GO:0030792
1323
Beta-2-microglobulin binding
GO:0030881
1076
Lipid antigen binding
GO:0030882
116
Endogenous lipid antigen binding
GO:0030883
118
Exogenous lipid antigen binding
GO:0030884
118
Actin-dependent ATPase activity
GO:0030898
1364
Calcium-dependent ATPase activity
GO:0030899
13
TPR domain binding
GO:0030911
9
Endoplasmic reticulum signal peptide binding
GO:0030942
7
Potassium ion binding
GO:0030955
1160
Tat protein binding
GO:0030957
590
Receptor tyrosine kinase binding
GO:0030971
2201
Thiamine binding
GO:0030975
1
Thiamine pyrophosphate binding
GO:0030976
1302
Taurine binding
GO:0030977
21
Mismatched DNA binding
GO:0030983
878
Kininogen binding
GO:0030984
456
Filamin binding
GO:0031005
3223
Troponin I binding
GO:0031013
5
Troponin T binding
GO:0031014
4
Cysteine desulfurase activity
GO:0031071
2
Heat shock protein binding
GO:0031072
3374
Cholesterol 26-hydroxylase activity
GO:0031073
1
POZ domain binding
GO:0031208
10
Phosphatidylcholine binding
GO:0031210
1132
Small GTPase binding
GO:0031267
1010
Translation initiation factor binding
GO:0031369
923
Eukaryotic initiation factor 4G binding
GO:0031370
302
Protein tag
GO:0031386
1131
Sodium ion binding
GO:0031402
886
Lithium ion binding
GO:0031403
907
Chloride ion binding
GO:0031404
66
Carboxylic acid binding
GO:0031406
35
L-ascorbic acid binding
GO:0031418
1649
Cobalamin binding
GO:0031419
1672
Titin binding
GO:0031432
52
Telethonin binding
GO:0031433
148
Mitogen-activated protein kinase kinase binding
GO:0031434
250
Mitogen-activated protein kinase kinase kinase binding
GO:0031435
2996
Myosin V binding
GO:0031489
2972
Chromatin DNA binding
GO:0031490
1607
Nucleosome binding
GO:0031491
1358
Nucleosomal DNA binding
GO:0031492
2548
Nucleosomal histone binding
GO:0031493
762
Thyrotropin-releasing hormone receptor binding
GO:0031531
3
Peptidyl-proline dioxygenase activity
GO:0031543
270
Peptidyl-proline 4-dioxygenase activity
GO:0031545
272
Polyubiquitin binding
GO:0031593
1208
Ubiquitin conjugating enzyme binding
GO:0031624
2260
Ubiquitin protein ligase binding
GO:0031625
5419
Beta-endorphin binding
GO:0031626
6
Opioid receptor binding
GO:0031628
575
G-protein beta-subunit binding
GO:0031681
2343
G-protein beta/gamma-subunit complex binding
GO:0031683
2146
Adenosine receptor binding
GO:0031685
1293
A1 adenosine receptor binding
GO:0031686
2
A2A adenosine receptor binding
GO:0031687
8
Alpha-1A adrenergic receptor binding
GO:0031691
2
Alpha-1B adrenergic receptor binding
GO:0031692
8
Alpha-2A adrenergic receptor binding
GO:0031694
11
Alpha-2B adrenergic receptor binding
GO:0031695
2
Alpha-2C adrenergic receptor binding
GO:0031696
8
Beta-1 adrenergic receptor binding
GO:0031697
18
Beta-2 adrenergic receptor binding
GO:0031698
24
Beta-3 adrenergic receptor binding
GO:0031699
16
Angiotensin receptor binding
GO:0031701
14
Type 1 angiotensin receptor binding
GO:0031702
51
Type 2 angiotensin receptor binding
GO:0031703
6
Apelin receptor binding
GO:0031704
6
Endothelin A receptor binding
GO:0031707
7
Endothelin B receptor binding
GO:0031708
7
Bradykinin receptor binding
GO:0031711
6
C5a anaphylatoxin chemotactic receptor binding
GO:0031714
4
C5L2 anaphylatoxin chemotactic receptor binding
GO:0031715
5
Haptoglobin binding
GO:0031720
1
Hemoglobin alpha binding
GO:0031721
3
CXCR5 chemokine receptor binding
GO:0031724
2
CCR1 chemokine receptor binding
GO:0031726
1124
CCR2 chemokine receptor binding
GO:0031727
8
CCR4 chemokine receptor binding
GO:0031729
1121
CCR5 chemokine receptor binding
GO:0031730
1134
CCR7 chemokine receptor binding
GO:0031732
1
CCR10 chemokine receptor binding
GO:0031735
5
Type B gastrin/cholecystokinin receptor binding
GO:0031741
2
D1 dopamine receptor binding
GO:0031748
32
D2 dopamine receptor binding
GO:0031749
12
D3 dopamine receptor binding
GO:0031750
13
D4 dopamine receptor binding
GO:0031751
12
D5 dopamine receptor binding
GO:0031752
13
Edg-2 lysophosphatidic acid receptor binding
GO:0031755
3
Follicle-stimulating hormone receptor binding
GO:0031762
2
Ghrelin receptor binding
GO:0031768
1
Growth hormone-releasing hormone receptor binding
GO:0031770
1
Type 1 hypocretin receptor binding
GO:0031771
1
Type 2 hypocretin receptor binding
GO:0031772
1
Corticotropin hormone receptor binding
GO:0031780
5
Type 3 melanocortin receptor binding
GO:0031781
5
Type 4 melanocortin receptor binding
GO:0031782
5
Type 5 melanocortin receptor binding
GO:0031783
5
Type 3 metabotropic glutamate receptor binding
GO:0031800
2
Type 5 metabotropic glutamate receptor binding
GO:0031802
4
P2Y1 nucleotide receptor binding
GO:0031812
7
G-protein coupled serotonin receptor binding
GO:0031821
7
Type 2A serotonin receptor binding
GO:0031826
11
Olfactory receptor binding
GO:0031849
11
Mu-type opioid receptor binding
GO:0031852
14
Pituitary adenylate cyclase-activating polypeptide receptor binding
GO:0031858
4
Prolactin-releasing peptide receptor binding
GO:0031861
1
EP4 subtype prostaglandin E2 receptor binding
GO:0031867
3
Thromboxane A2 receptor binding
GO:0031870
207
Proteinase activated receptor binding
GO:0031871
6
Somatostatin receptor binding
GO:0031877
9
Taste receptor binding
GO:0031883
3
V1A vasopressin receptor binding
GO:0031894
678
V1B vasopressin receptor binding
GO:0031895
1
Very long-chain fatty acid-CoA ligase activity
GO:0031957
4
Insulin-like growth factor I binding
GO:0031994
59
Insulin-like growth factor II binding
GO:0031995
51
Thioesterase binding
GO:0031996
731
Myosin light chain binding
GO:0032027
10
Myosin head/neck binding
GO:0032028
3
Myosin tail binding
GO:0032029
18
Myosin heavy chain binding
GO:0032036
265
Myosin II heavy chain binding
GO:0032038
3
NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032041
1210
Clathrin heavy chain binding
GO:0032050
952
Clathrin light chain binding
GO:0032051
406
Bile acid binding
GO:0032052
133
NACHT domain binding
GO:0032089
1422
Pyrin domain binding
GO:0032090
5
Guanine/thymine mispair binding
GO:0032137
861
Single base insertion or deletion binding
GO:0032138
2
Dinucleotide insertion or deletion binding
GO:0032139
860
Single guanine insertion binding
GO:0032142
861
Single thymine insertion binding
GO:0032143
3
Succinate-semialdehyde dehydrogenase binding
GO:0032145
7
Dinucleotide repeat insertion binding
GO:0032181
859
SUMO binding
GO:0032183
23
SUMO polymer binding
GO:0032184
268
Acrosin binding
GO:0032190
7
Phosphatidylinositol-3-phosphate binding
GO:0032266
3197
Oxidized purine DNA binding
GO:0032357
861
MHC class I receptor activity
GO:0032393
1388
MHC class II receptor activity
GO:0032395
797
Inhibitory MHC class I receptor activity
GO:0032396
22
Protein complex binding
GO:0032403
5517
MutLalpha complex binding
GO:0032405
15
MutLbeta complex binding
GO:0032406
6
MutSalpha complex binding
GO:0032407
13
MutSbeta complex binding
GO:0032408
6
Purine-rich negative regulatory element binding
GO:0032422
4
GBD domain binding
GO:0032427
6
Beta-N-acetylgalactosaminidase activity
GO:0032428
754
DNA hairpin binding
GO:0032448
15
Maltose alpha-glucosidase activity
GO:0032450
6
Demethylase activity
GO:0032451
1812
Histone demethylase activity
GO:0032452
33
Histone demethylase activity (H3-K9 specific)
GO:0032454
20
Muramyl dipeptide binding
GO:0032500
6
Sulfiredoxin activity
GO:0032542
7
Ribonucleoside binding
GO:0032549
425
Pyrimidine ribonucleotide binding
GO:0032557
2
DATP binding
GO:0032564
2
Copper-dependent protein binding
GO:0032767
455
Lead ion binding
GO:0032791
2
GTPase activating protein binding
GO:0032794
956
Heterotrimeric G-protein binding
GO:0032795
9
Sterol response element binding
GO:0032810
7
Tumor necrosis factor receptor superfamily binding
GO:0032813
136
Calcitonin binding
GO:0032841
6
Protein complex scaffold
GO:0032947
2243
Bitter taste receptor activity
GO:0033038
28
Sour taste receptor activity
GO:0033040
9
Sweet taste receptor activity
GO:0033041
7
Acetylcholine receptor binding
GO:0033130
39
Progesterone receptor binding
GO:0033142
16
FFAT motif binding
GO:0033149
415
Glycolipid 6-alpha-mannosyltransferase activity
GO:0033164
3
Sphingomyelin synthase activity
GO:0033188
9
Calmodulin-dependent protein phosphatase activity
GO:0033192
57
Ribonuclease P RNA binding
GO:0033204
3
Choline binding
GO:0033265
289
Dehydroascorbic acid transporter activity
GO:0033300
14
MAP kinase phosphatase activity
GO:0033549
8
Protein deacetylase activity
GO:0033558
1159
Activating transcription factor binding
GO:0033613
1822
DNA/RNA helicase activity
GO:0033677
4
ATP-dependent 5'-3' DNA/RNA helicase activity
GO:0033682
2
Sialic acid binding
GO:0033691
1586
1-pyrroline dehydrogenase activity
GO:0033737
2
Peptide-methionine (R)-S-oxide reductase activity
GO:0033743
943
Histone demethylase activity (H3-R2 specific)
GO:0033746
748
Histone demethylase activity (H4-R3 specific)
GO:0033749
748
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
GO:0033778
675
Taurochenodeoxycholate 6alpha-hydroxylase activity
GO:0033780
374
Thyroxine 5-deiodinase activity
GO:0033798
2
Propanoyl-CoA C-acyltransferase activity
GO:0033814
8
Procollagen glucosyltransferase activity
GO:0033823
5
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0033829
11
N-acetylgalactosamine kinase activity
GO:0033858
215
[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity
GO:0033871
1
[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
GO:0033872
4
Hormone-sensitive lipase activity
GO:0033878
4
Pyridoxal phosphatase activity
GO:0033883
2
Ribonuclease T2 activity
GO:0033897
4
Hyaluronoglucuronidase activity
GO:0033906
2
Cis-stilbene-oxide hydrolase activity
GO:0033961
1
Deoxyhypusine synthase activity
GO:0034038
96
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0034039
5
Lipid-transporting ATPase activity
GO:0034040
10
Poly(G) RNA binding
GO:0034046
16
Estrogen response element binding
GO:0034056
501
DNA polymerase activity
GO:0034061
3
Apolipoprotein binding
GO:0034185
63
Apolipoprotein A-I receptor activity
GO:0034188
11
Very-low-density lipoprotein particle binding
GO:0034189
7
Apolipoprotein receptor binding
GO:0034190
6
Apolipoprotein A-I receptor binding
GO:0034191
288
GTP-dependent protein kinase activity
GO:0034211
11
GPI anchor binding
GO:0034235
1386
Protein kinase A catalytic subunit binding
GO:0034236
54
Protein kinase A regulatory subunit binding
GO:0034237
48
Bisphosphoglycerate 3-phosphatase activity
GO:0034417
4
Glycoprotein transporter activity
GO:0034437
3
Ubiquitin-ubiquitin ligase activity
GO:0034450
68
Dynactin binding
GO:0034452
48
3'-5' RNA helicase activity
GO:0034458
2
U3 snoRNA binding
GO:0034511
2
Fumarylpyruvate hydrolase activity
GO:0034545
700
PiRNA binding
GO:0034584
857
L-hydroxyproline transmembrane transporter activity
GO:0034590
12
Phosphatidylinositol bisphosphate phosphatase activity
GO:0034593
8
Phosphatidylinositol trisphosphate phosphatase activity
GO:0034594
9
Phosphatidylinositol phosphate 5-phosphatase activity
GO:0034595
15
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:0034597
9
Oxoglutarate dehydrogenase (NAD+) activity
GO:0034602
708
Tetrahydrobiopterin binding
GO:0034617
1489
Arginine binding
GO:0034618
1487
Retinol transporter activity
GO:0034632
1
Tripeptidase activity
GO:0034701
240
Inhibin binding
GO:0034711
30
Type I transforming growth factor beta receptor binding
GO:0034713
738
Type III transforming growth factor beta receptor binding
GO:0034714
4
Gamma-glutamyl-peptidase activity
GO:0034722
2
Cholesterol O-acyltransferase activity
GO:0034736
1408
Caffeine oxidase activity
GO:0034875
1559
Trimethylamine monooxygenase activity
GO:0034899
1
NAD-dependent protein deacetylase activity
GO:0034979
5
Iron chaperone activity
GO:0034986
1923
Immunoglobulin receptor binding
GO:0034987
8
Fc-gamma receptor I complex binding
GO:0034988
6
Phosphatidylinositol 3-kinase activity
GO:0035004
1422
1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035005
2042
Phosphatidylinositol 3-kinase regulator activity
GO:0035014
493
Histone deacetylase regulator activity
GO:0035033
257
Histone acetyltransferase regulator activity
GO:0035034
2
Histone acetyltransferase binding
GO:0035035
1494
Methylated histone residue binding
GO:0035064
3342
Phosphatidylinositol binding
GO:0035091
3734
Histone kinase activity
GO:0035173
13
Histone serine kinase activity
GO:0035174
2018
SiRNA binding
GO:0035197
717
MiRNA binding
GO:0035198
1513
Glutamate-cysteine ligase catalytic subunit binding
GO:0035226
1043
Dopamine binding
GO:0035240
23
Protein-arginine omega-N monomethyltransferase activity
GO:0035241
197
Protein-arginine omega-N asymmetric methyltransferase activity
GO:0035242
212
Protein-arginine omega-N symmetric methyltransferase activity
GO:0035243
200
Alpha-1,4-N-acetylgalactosaminyltransferase activity
GO:0035248
4
UDP-galactosyltransferase activity
GO:0035250
7
Glutamate receptor binding
GO:0035254
17
Ionotropic glutamate receptor binding
GO:0035255
160
G-protein coupled glutamate receptor binding
GO:0035256
6
Nuclear hormone receptor binding
GO:0035257
2516
Steroid hormone receptor binding
GO:0035258
15
Glucocorticoid receptor binding
GO:0035259
71
Ethanol binding
GO:0035276
15
Inositol pentakisphosphate 2-kinase activity
GO:0035299
1
5'-3' exodeoxyribonuclease activity
GO:0035312
3
Toll-like receptor binding
GO:0035325
2
Enhancer binding
GO:0035326
1730
Selenocysteine insertion sequence binding
GO:0035368
2
Chondroitin sulfate proteoglycan binding
GO:0035373
322
Chondroitin sulfate binding
GO:0035374
501
Zymogen binding
GO:0035375
5
Carbon dioxide transmembrane transporter activity
GO:0035379
11
Histone kinase activity (H3-Y41 specific)
GO:0035401
11
Histone kinase activity (H3-T11 specific)
GO:0035402
653
Histone kinase activity (H3-T6 specific)
GO:0035403
902
Cyclic-di-GMP binding
GO:0035438
2
Choriogonadotropin hormone receptor activity
GO:0035472
3
Lipase binding
GO:0035473
2779
CAMP response element binding
GO:0035497
752
MH2 domain binding
GO:0035500
738
MH1 domain binding
GO:0035501
738
Oxidative RNA demethylase activity
GO:0035515
719
Oxidative DNA demethylase activity
GO:0035516
718
NADH pyrophosphatase activity
GO:0035529
831
Carbohydrate response element binding
GO:0035538
12
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0035539
468
Histone demethylase activity (H4-K20 specific)
GO:0035575
5
Signaling adaptor activity
GO:0035591
309
Ganglioside binding
GO:0035594
4
N6-threonylcarbomyladenosine methylthiotransferase activity
GO:0035598
911
AP-2 adaptor complex binding
GO:0035612
2273
RNA stem-loop binding
GO:0035613
13
Clathrin adaptor activity
GO:0035615
23
Ceramide transporter activity
GO:0035620
5
Histone methyltransferase activity (H3-R17 specific)
GO:0035642
3
AP-1 adaptor complex binding
GO:0035650
1
AP-3 adaptor complex binding
GO:0035651
1
Toll-like receptor 4 binding
GO:0035662
248
Toll-like receptor 2 binding
GO:0035663
244
Macrophage migration inhibitory factor binding
GO:0035718
2
Lysophosphatidic acid binding
GO:0035727
3
S-nitrosoglutathione binding
GO:0035730
2
Dinitrosyl-iron complex binding
GO:0035731
2
Chemokine (C-C motif) ligand 19 binding
GO:0035757
4
Chemokine (C-C motif) ligand 21 binding
GO:0035758
4
Ubiquitin-specific protease activator activity
GO:0035800
4
Rubidium ion transmembrane transporter activity
GO:0035827
1680
Krueppel-associated box domain binding
GO:0035851
1015
DITP diphosphatase activity
GO:0035870
12
Death effector domain binding
GO:0035877
2677
MRNA 3'-UTR AU-rich region binding
GO:0035925
29
Microsatellite binding
GO:0035939
7
Pre-mRNA binding
GO:0036002
7
Mediator complex binding
GO:0036033
21
Long-chain fatty acid binding
GO:0036041
4
Long-chain fatty acyl-CoA binding
GO:0036042
9
Protein-malonyllysine demalonylase activity
GO:0036054
713
Protein-succinyllysine desuccinylase activity
GO:0036055
713
Small molecule binding
GO:0036094
11
Peroxisome membrane class-1 targeting sequence binding
GO:0036105
3
BMP binding
GO:0036122
7
Peptidyl-histidine dioxygenase activity
GO:0036139
20
Peptidyl-asparagine 3-dioxygenase activity
GO:0036140
20
ITP diphosphatase activity
GO:0036220
2
XTP diphosphatase activity
GO:0036222
2
NA
GO:0036310
838
NA
GO:0036312
6
NA
GO:0036313
3
NA
GO:0036326
629
NA
GO:0036327
629
NA
GO:0036332
629
NA
GO:0036374
745
NA
GO:0036393
2
NA
GO:0036403
66
NA
GO:0036459
3819
NA
GO:0036461
1
NA
GO:0036468
1
NA
GO:0036470
1
NA
GO:0036478
1
NA
GO:0036479
11
NA
GO:0036487
8
Signaling receptor activity
GO:0038023
607
Cargo receptor activity
GO:0038024
6
Reelin receptor activity
GO:0038025
16
Morphine receptor activity
GO:0038047
1710
Dynorphin receptor activity
GO:0038048
801
Ligand-activated RNA polymerase II transcription factor binding transcription factor activity
GO:0038049
16
Glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
GO:0038051
9
Estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0038052
8
Protein tyrosine kinase collagen receptor activity
GO:0038062
10
Collagen receptor activity
GO:0038064
737
Vascular endothelial growth factor binding
GO:0038085
199
Nodal binding
GO:0038100
13
Choriogonadotropin hormone binding
GO:0038106
3
C-C motif chemokine 19 receptor activity
GO:0038117
4
C-C motif chemokine 21 receptor activity
GO:0038121
4
NA
GO:0038181
126
NA
GO:0038186
415
NA
GO:0038191
6
Interleukin-18 binding
GO:0042007
3
Interleukin-18 receptor activity
GO:0042008
2
Interleukin-20 binding
GO:0042015
5
Interleukin-22 binding
GO:0042017
6
Interleukin-22 receptor activity
GO:0042018
6
Interleukin-23 binding
GO:0042019
937
Interleukin-23 receptor activity
GO:0042020
937
ATPase inhibitor activity
GO:0042030
8
Neurexin family protein binding
GO:0042043
546
Histone methyltransferase activity
GO:0042054
30
Chemoattractant activity
GO:0042056
1520
Thiamine phosphate phosphatase activity
GO:0042131
283
Fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042132
2
RRNA primary transcript binding
GO:0042134
432
Telomeric DNA binding
GO:0042162
1299
Interleukin-12 beta subunit binding
GO:0042163
2
Interleukin-12 alpha subunit binding
GO:0042164
134
Neurotransmitter binding
GO:0042165
8
Acetylcholine binding
GO:0042166
1311
SH2 domain binding
GO:0042169
2343
Lysophosphatidic acid acyltransferase activity
GO:0042171
104
Peptide binding
GO:0042277
2897
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
GO:0042281
69
Hydroxymethylglutaryl-CoA reductase activity
GO:0042282
4
Xylosyltransferase activity
GO:0042285
3
MHC protein binding
GO:0042287
853
MHC class I protein binding
GO:0042288
2508
MHC class II protein binding
GO:0042289
9
ISG15 ligase activity
GO:0042296
5
Phosphate ion binding
GO:0042301
1153
Heparan sulfate N-acetylglucosaminyltransferase activity
GO:0042328
3
Chemokine receptor binding
GO:0042379
1131
Sphingosine-1-phosphate phosphatase activity
GO:0042392
3
Histone binding
GO:0042393
4835
Diacyl lipopeptide binding
GO:0042498
652
Aspartic endopeptidase activity, intramembrane cleaving
GO:0042500
9
Hormone binding
GO:0042562
31
Phosphoric ester hydrolase activity
GO:0042578
148
Riboflavin reductase (NADPH) activity
GO:0042602
1
Peptide antigen binding
GO:0042605
3427
T cell receptor binding
GO:0042608
627
CD4 receptor binding
GO:0042609
15
CD8 receptor binding
GO:0042610
8
ATPase activity, coupled
GO:0042623
27
ATPase activity, uncoupled
GO:0042624
1
ATPase activity, coupled to transmembrane movement of ions
GO:0042625
2
ATPase activity, coupled to transmembrane movement of substances
GO:0042626
1714
MHC class II protein binding, via antigen binding groove
GO:0042658
2
PH domain binding
GO:0042731
13
Histone methyltransferase activity (H4-K20 specific)
GO:0042799
15
Histone methyltransferase activity (H3-K4 specific)
GO:0042800
57
Polo kinase kinase activity
GO:0042801
546
Identical protein binding
GO:0042802
6993
Protein homodimerization activity
GO:0042803
7150
Actinin binding
GO:0042805
1772
Fucose binding
GO:0042806
243
Vitamin D receptor binding
GO:0042809
448
Wnt-activated receptor activity
GO:0042813
2061
Histone deacetylase binding
GO:0042826
3712
Peptidoglycan binding
GO:0042834
360
Antibiotic transporter activity
GO:0042895
788
Tubulin deacetylase activity
GO:0042903
3
Xenobiotic transporter activity
GO:0042910
2
Neuropeptide binding
GO:0042923
2550
Dipeptide transporter activity
GO:0042936
787
Lipoprotein transporter activity
GO:0042954
11
Retinoic acid receptor binding
GO:0042974
194
Peroxisome proliferator activated receptor binding
GO:0042975
2081
Ornithine decarboxylase activator activity
GO:0042978
121
X11-like protein binding
GO:0042988
2
ATP-dependent protein binding
GO:0043008
27
Alpha-tubulin binding
GO:0043014
1114
Gamma-tubulin binding
GO:0043015
1611
Ribonucleoprotein complex binding
GO:0043021
923
Ribosome binding
GO:0043022
2577
Ribosomal large subunit binding
GO:0043023
356
Ribosomal small subunit binding
GO:0043024
892
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043027
2893
Cysteine-type endopeptidase regulator activity involved in apoptotic process
GO:0043028
1
Chromatin insulator sequence binding
GO:0043035
3
Single-stranded telomeric DNA binding
GO:0043047
17
Tumor necrosis factor binding
GO:0043120
6
Neurotrophin binding
GO:0043121
29
ErbB-3 class receptor binding
GO:0043125
34
Ubiquitin binding
GO:0043130
2874
3'-5' DNA helicase activity
GO:0043138
6
5'-3' DNA helicase activity
GO:0043139
8
ATP-dependent 3'-5' DNA helicase activity
GO:0043140
212
ATP-dependent 5'-3' DNA helicase activity
GO:0043141
7
Single-stranded DNA-dependent ATPase activity
GO:0043142
596
Ion binding
GO:0043167
53
Cation binding
GO:0043169
209
Amine binding
GO:0043176
2
Organic acid binding
GO:0043177
6
Alcohol binding
GO:0043178
4
Vascular endothelial growth factor receptor 1 binding
GO:0043183
8
Vascular endothelial growth factor receptor 2 binding
GO:0043184
24
Vascular endothelial growth factor receptor 3 binding
GO:0043185
3
Sulfate binding
GO:0043199
5
Glycosphingolipid binding
GO:0043208
24
Laminin binding
GO:0043236
2625
Laminin-1 binding
GO:0043237
456
Adenosine-diphosphatase activity
GO:0043262
18
Phospholipase binding
GO:0043274
87
Glutathione binding
GO:0043295
1572
Phosphatidylinositol-3,4-bisphosphate binding
GO:0043325
1260
Proteoglycan binding
GO:0043394
2595
Heparan sulfate proteoglycan binding
GO:0043395
372
HLH domain binding
GO:0043398
216
Corticotropin-releasing hormone receptor activity
GO:0043404
6
Protein kinase B binding
GO:0043422
895
3-phosphoinositide-dependent protein kinase binding
GO:0043423
7
BHLH transcription factor binding
GO:0043425
347
MRF binding
GO:0043426
38
Protein anchor
GO:0043495
550
Kinetochore binding
GO:0043515
414
Leucine zipper domain binding
GO:0043522
2060
ADP binding
GO:0043531
2394
Angiostatin binding
GO:0043532
15
Protein serine/threonine kinase activator activity
GO:0043539
273
Molybdopterin cofactor binding
GO:0043546
275
Phosphatidylinositol 3-kinase binding
GO:0043548
90
Insulin binding
GO:0043559
61
Insulin receptor substrate binding
GO:0043560
772
Sequence-specific DNA binding
GO:0043565
6209
Structure-specific DNA binding
GO:0043566
1271
Protein self-association
GO:0043621
2000
DNA-N1-methyladenine dioxygenase activity
GO:0043734
721
Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
GO:0043754
1769
Phosphatidylinositol-4-phosphate phosphatase activity
GO:0043812
8
Phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
GO:0043813
506
Ras palmitoyltransferase activity
GO:0043849
12
Acireductone synthase activity
GO:0043874
2
NADPH:sulfur oxidoreductase activity
GO:0043914
9
Suramin binding
GO:0043924
8
Histone acetyltransferase activity (H4-K5 specific)
GO:0043995
587
Histone acetyltransferase activity (H4-K8 specific)
GO:0043996
587
Histone methyltransferase activity (H4-R3 specific)
GO:0044020
197
Protein binding involved in protein folding
GO:0044183
459
Transcription regulatory region DNA binding
GO:0044212
3987
Retinoic acid-responsive element binding
GO:0044323
14
Ion channel binding
GO:0044325
3572
Small protein activating enzyme binding
GO:0044388
1
Small protein conjugating enzyme binding
GO:0044390
1
L-cystine L-cysteine-lyase (deaminating)
GO:0044540
301
S100 protein binding
GO:0044548
525
GTP cyclohydrolase binding
GO:0044549
1
FMN transmembrane transporter activity
GO:0044610
2
NA
GO:0044729
758
NA
GO:0044822
7849
G-protein coupled purinergic nucleotide receptor activity
GO:0045028
1771
UDP-activated nucleotide receptor activity
GO:0045029
3
ATP-activated nucleotide receptor activity
GO:0045031
2
ADP-activated nucleotide receptor activity
GO:0045032
2
Bioactive lipid receptor activity
GO:0045125
1
Uridine-diphosphatase activity
GO:0045134
943
Single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
GO:0045145
610
Electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
GO:0045155
1949
Myosin II binding
GO:0045159
903
Glutathione dehydrogenase (ascorbate) activity
GO:0045174
1
Translation regulator activity
GO:0045182
182
CXCR chemokine receptor binding
GO:0045236
8
Alpha-catenin binding
GO:0045294
158
Gamma-catenin binding
GO:0045295
1133
Cadherin binding
GO:0045296
168
Protein phosphorylated amino acid binding
GO:0045309
755
Unmethylated CpG binding
GO:0045322
17
Mercury ion binding
GO:0045340
1
Interleukin-1 Type I receptor antagonist activity
GO:0045352
1
Interleukin-1 Type II receptor antagonist activity
GO:0045353
1
Chemorepellent activity
GO:0045499
37
Dynein binding
GO:0045502
214
Dynein light chain binding
GO:0045503
6
Dynein heavy chain binding
GO:0045504
1
Dynein intermediate chain binding
GO:0045505
38
Interleukin-27 receptor activity
GO:0045509
229
Interleukin-27 binding
GO:0045513
2
Interleukin-20 receptor binding
GO:0045517
1
Interleukin-22 receptor binding
GO:0045518
2
Interleukin-23 receptor binding
GO:0045519
134
Interleukin-27 receptor binding
GO:0045523
20
Syndecan binding
GO:0045545
1437
Geranylgeranyl reductase activity
GO:0045550
453
TRAIL binding
GO:0045569
1196
SMAD binding
GO:0046332
2976
Polynucleotide 3'-phosphatase activity
GO:0046403
2
ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0046404
653
S-methyl-5-thioribose-1-phosphate isomerase activity
GO:0046523
1733
Glucosyltransferase activity
GO:0046527
4
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0046538
1
Histamine N-methyltransferase activity
GO:0046539
150
Malate dehydrogenase (NADP+) activity
GO:0046554
2
Long-chain-alcohol oxidase activity
GO:0046577
292
Rap GTPase activator activity
GO:0046582
27
Polyamine oxidase activity
GO:0046592
1
Sphingolipid transporter activity
GO:0046624
7
Sphingolipid binding
GO:0046625
10
Natural killer cell lectin-like receptor binding
GO:0046703
1615
Borate transmembrane transporter activity
GO:0046715
3
Host cell surface receptor binding
GO:0046789
3
Virion binding
GO:0046790
985
Histone deacetylase inhibitor activity
GO:0046811
4
Chemokine receptor antagonist activity
GO:0046817
1121
Hydroxyapatite binding
GO:0046848
2
Cadmium ion binding
GO:0046870
1768
Metal ion binding
GO:0046872
8920
Metal ion transmembrane transporter activity
GO:0046873
341
Ephrin receptor binding
GO:0046875
1845
Calcium oxalate binding
GO:0046904
1
Transition metal ion binding
GO:0046914
5
Transition metal ion transmembrane transporter activity
GO:0046915
205
Alpha-(1->3)-fucosyltransferase activity
GO:0046920
1658
Alpha-(1->6)-fucosyltransferase activity
GO:0046921
28
Peptide-O-fucosyltransferase activity
GO:0046922
848
ER retention sequence binding
GO:0046923
9
Hydrogen ion transporting ATP synthase activity, rotational mechanism
GO:0046933
893
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046934
727
1-phosphatidylinositol-3-kinase regulator activity
GO:0046935
16
Carboxylic acid transmembrane transporter activity
GO:0046943
2
Proton-transporting ATPase activity, rotational mechanism
GO:0046961
1825
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
GO:0046964
4
Retinoid X receptor binding
GO:0046965
824
Thyroid hormone receptor binding
GO:0046966
1331
NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046969
1068
NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0046970
1062
Histone acetyltransferase activity (H4-K16 specific)
GO:0046972
587
Histone methyltransferase activity (H3-K9 specific)
GO:0046974
241
Histone methyltransferase activity (H3-K36 specific)
GO:0046975
20
Histone methyltransferase activity (H3-K27 specific)
GO:0046976
22
TAP binding
GO:0046977
1
TAP1 binding
GO:0046978
1384
TAP2 binding
GO:0046979
1382
Tapasin binding
GO:0046980
2
Protein heterodimerization activity
GO:0046982
5758
Protein dimerization activity
GO:0046983
4847
Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0047012
2
Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
GO:0047016
339
Androsterone dehydrogenase activity
GO:0047023
1
Testosterone dehydrogenase (NAD+) activity
GO:0047035
165
Testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047045
1
Vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0047057
6
4-trimethylammoniobutyraldehyde dehydrogenase activity
GO:0047105
2
Saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
GO:0047130
915
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
GO:0047131
915
Protein-disulfide reductase activity
GO:0047134
923
Betaine-homocysteine S-methyltransferase activity
GO:0047150
999
Platelet-activating factor acetyltransferase activity
GO:0047179
1108
1-acylglycerophosphocholine O-acyltransferase activity
GO:0047184
591
Cysteine-S-conjugate N-acetyltransferase activity
GO:0047198
5
Galactosylxylosylprotein 3-beta-galactosyltransferase activity
GO:0047220
5
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
GO:0047223
708
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0047225
1
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0047238
392
Galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity
GO:0047273
190
Globoside alpha-N-acetylgalactosaminyltransferase activity
GO:0047277
3
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
GO:0047290
1
(S)-3-amino-2-methylpropionate transaminase activity
GO:0047298
7
Kynurenine-glyoxylate transaminase activity
GO:0047315
3
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0047322
918
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO:0047323
2
Inositol tetrakisphosphate 1-kinase activity
GO:0047325
664
Fucose-1-phosphate guanylyltransferase activity
GO:0047341
3
Acylglycerol lipase activity
GO:0047372
10
Methylumbelliferyl-acetate deacetylase activity
GO:0047374
4
Glycerophosphocholine cholinephosphodiesterase activity
GO:0047390
346
Glycerophosphoinositol inositolphosphodiesterase activity
GO:0047394
120
Alkenylglycerophosphocholine hydrolase activity
GO:0047408
1
Alkenylglycerophosphoethanolamine hydrolase activity
GO:0047409
1
Nucleoside-triphosphate diphosphatase activity
GO:0047429
826
17-alpha-hydroxyprogesterone aldolase activity
GO:0047442
4
Protein N-terminus binding
GO:0047485
4034
Ceramide cholinephosphotransferase activity
GO:0047493
9
Calcium-dependent phospholipase A2 activity
GO:0047498
590
Calcium-independent phospholipase A2 activity
GO:0047499
25
2-hydroxyglutarate dehydrogenase activity
GO:0047545
1217
3',5'-cyclic-GMP phosphodiesterase activity
GO:0047555
2731
7-dehydrocholesterol reductase activity
GO:0047598
2
Acyl-CoA hydrolase activity
GO:0047617
687
Acylpyruvate hydrolase activity
GO:0047621
700
ADP-ribose diphosphatase activity
GO:0047631
23
Albendazole monooxygenase activity
GO:0047638
374
Arachidonate-CoA ligase activity
GO:0047676
3
ATP diphosphatase activity
GO:0047693
1
Beta-adrenergic receptor kinase activity
GO:0047696
2
Bile-salt sulfotransferase activity
GO:0047704
813
Biotinidase activity
GO:0047708
3
Bis(5'-adenosyl)-triphosphatase activity
GO:0047710
5
Indanol dehydrogenase activity
GO:0047718
453
Iron-cytochrome-c reductase activity
GO:0047726
4
Chlordecone reductase activity
GO:0047743
1
Cholate-CoA ligase activity
GO:0047747
1
Cholestanetriol 26-monooxygenase activity
GO:0047749
1
Cholestenol delta-isomerase activity
GO:0047750
1
Cholestenone 5-alpha-reductase activity
GO:0047751
4
Chondroitin 4-sulfotransferase activity
GO:0047756
161
Chondroitin-glucuronate 5-epimerase activity
GO:0047757
2
Butyrate-CoA ligase activity
GO:0047760
9
Corticosterone 18-monooxygenase activity
GO:0047783
2
Delta4-3-oxosteroid 5beta-reductase activity
GO:0047787
626
L-cysteine:2-oxoglutarate aminotransferase activity
GO:0047801
1
Cysteine-S-conjugate beta-lyase activity
GO:0047804
3
Deoxycytidine deaminase activity
GO:0047844
702
Dihydrocoumarin hydrolase activity
GO:0047856
1
Dolichyldiphosphatase activity
GO:0047874
2
Flavonol 3-sulfotransferase activity
GO:0047894
236
L-glucuronate reductase activity
GO:0047939
60
Glycine N-acyltransferase activity
GO:0047961
8
Glycine N-benzoyltransferase activity
GO:0047962
4
Glycine N-choloyltransferase activity
GO:0047963
3
Glyoxylate oxidase activity
GO:0047969
2
Hepoxilin-epoxide hydrolase activity
GO:0047977
193
Homocysteine desulfhydrase activity
GO:0047982
301
Hydroxyacid-oxoacid transhydrogenase activity
GO:0047988
1
Receptor agonist activity
GO:0048018
38
Receptor antagonist activity
GO:0048019
2655
CCR chemokine receptor binding
GO:0048020
2
MRNA 5'-UTR binding
GO:0048027
46
Monosaccharide binding
GO:0048029
2234
Cofactor binding
GO:0048037
167
Quinone binding
GO:0048038
26
Calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101
15
Tau protein binding
GO:0048156
75
Activin binding
GO:0048185
524
Phytanoyl-CoA dioxygenase activity
GO:0048244
2
CXCR3 chemokine receptor binding
GO:0048248
9
Flap endonuclease activity
GO:0048256
7
3'-flap endonuclease activity
GO:0048257
2
Methionine adenosyltransferase regulator activity
GO:0048270
2
Mitogen-activated protein kinase p38 binding
GO:0048273
1122
Calcium-dependent protein binding
GO:0048306
1880
Rac GTPase binding
GO:0048365
1193
Brain-derived neurotrophic factor binding
GO:0048403
29
Nerve growth factor binding
GO:0048406
19
Platelet-derived growth factor binding
GO:0048407
63
Epidermal growth factor binding
GO:0048408
10
Beta-tubulin binding
GO:0048487
1222
Roundabout binding
GO:0048495
67
Calcium-induced calcium release activity
GO:0048763
233
L-fuconate dehydratase activity
GO:0050023
511
L-pipecolate oxidase activity
GO:0050031
566
Leukotriene-B4 20-monooxygenase activity
GO:0050051
50
Long-chain-aldehyde dehydrogenase activity
GO:0050061
292
M7G(5')pppN diphosphatase activity
GO:0050072
1397
Malonyl-CoA decarboxylase activity
GO:0050080
2
L-gulonate 3-dehydrogenase activity
GO:0050104
1
N-acylneuraminate-9-phosphatase activity
GO:0050124
270
N-formylglutamate deformylase activity
GO:0050129
7
NAD(P)+ nucleosidase activity
GO:0050135
61
Nucleoside phosphate kinase activity
GO:0050145
5
Nucleoside phosphotransferase activity
GO:0050146
644
Fucokinase activity
GO:0050201
4
Procollagen galactosyltransferase activity
GO:0050211
479
Prostaglandin-E synthase activity
GO:0050220
536
Retinol O-fatty-acyltransferase activity
GO:0050252
4
Rhodopsin kinase activity
GO:0050254
3
RNA uridylyltransferase activity
GO:0050265
20
Sphingosine N-acyltransferase activity
GO:0050291
572
Steroid sulfotransferase activity
GO:0050294
248
Tau-protein kinase activity
GO:0050321
1544
Thiamin-triphosphatase activity
GO:0050333
5
Trans-octaprenyltranstransferase activity
GO:0050347
734
Trimethyllysine dioxygenase activity
GO:0050353
1
[acetyl-CoA carboxylase] kinase activity
GO:0050405
918
Calcium-dependent phospholipase C activity
GO:0050429
3
Transforming growth factor beta binding
GO:0050431
1596
Microfibril binding
GO:0050436
3
Arachidonate 15-lipoxygenase activity
GO:0050473
267
Hyaluronan synthase activity
GO:0050501
10
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0050508
8
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
GO:0050509
3
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
GO:0050510
385
Acyloxyacyl hydrolase activity
GO:0050528
5
Icosatetraenoic acid binding
GO:0050543
4
Arachidonic acid binding
GO:0050544
546
Aspartate-tRNA(Asn) ligase activity
GO:0050560
1
Glutamate-tRNA(Gln) ligase activity
GO:0050561
6
Glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
GO:0050567
1347
Quinine 3-monooxygenase activity
GO:0050591
374
Methylarsonate reductase activity
GO:0050610
1
Delta14-sterol reductase activity
GO:0050613
4
Delta24-sterol reductase activity
GO:0050614
6
5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050646
2
5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050647
2
5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050648
2
Testosterone 6-beta-hydroxylase activity
GO:0050649
374
3'-phosphoadenosine 5'-phosphosulfate binding
GO:0050656
1315
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
GO:0050659
25
Flavin adenine dinucleotide binding
GO:0050660
4569
NADP binding
GO:0050661
2819
Coenzyme binding
GO:0050662
304
Androgen receptor binding
GO:0050681
2333
AF-2 domain binding
GO:0050682
79
AF-1 domain binding
GO:0050683
1
LBD domain binding
GO:0050693
14
Galactose 3-O-sulfotransferase activity
GO:0050694
664
Proteoglycan sulfotransferase activity
GO:0050698
664
WW domain binding
GO:0050699
2078
CARD domain binding
GO:0050700
2655
RS domain binding
GO:0050733
1288
Low-density lipoprotein particle receptor binding
GO:0050750
2745
Dopamine receptor binding
GO:0050780
1
RAGE receptor binding
GO:0050786
11
GABA receptor binding
GO:0050811
728
Phosphoserine binding
GO:0050815
160
Phosphothreonine binding
GO:0050816
8
Toxin receptor binding
GO:0050827
6
Pyruvate transmembrane transporter activity
GO:0050833
1174
Cell adhesion molecule binding
GO:0050839
3359
Extracellular matrix binding
GO:0050840
336
Cobalt ion binding
GO:0050897
701
Nitric-oxide synthase binding
GO:0050998
1104
Microtubule plus-end binding
GO:0051010
246
Microtubule minus-end binding
GO:0051011
16
Actin filament binding
GO:0051015
4140
Protein kinase A binding
GO:0051018
346
Mitogen-activated protein kinase binding
GO:0051019
114
GTPase binding
GO:0051020
1485
GDP-dissociation inhibitor binding
GO:0051021
3
Rho GDP-dissociation inhibitor binding
GO:0051022
2
RNA transmembrane transporter activity
GO:0051033
230
NF-kappaB binding
GO:0051059
1353
Unfolded protein binding
GO:0051082
4538
Chaperone binding
GO:0051087
3545
ATPase binding
GO:0051117
4412
Hepoxilin A3 synthase activity
GO:0051120
196
Metal ion:hydrogen antiporter activity
GO:0051139
205
Vitamin transporter activity
GO:0051183
4
Dioxygenase activity
GO:0051213
1510
Phosphoprotein binding
GO:0051219
2066
Mono-olein transacylation activity
GO:0051264
557
Diolein transacylation activity
GO:0051265
557
CP2 mannose-ethanolamine phosphotransferase activity
GO:0051267
1
NAD binding
GO:0051287
1917
Muscle alpha-actinin binding
GO:0051371
1577
FATZ binding
GO:0051373
4
Serotonin binding
GO:0051378
527
Epinephrine binding
GO:0051379
29
Norepinephrine binding
GO:0051380
25
Alpha-actinin binding
GO:0051393
1236
BH domain binding
GO:0051400
12
Corticotropin-releasing hormone binding
GO:0051424
6
PTB domain binding
GO:0051425
763
Hormone receptor binding
GO:0051427
1310
Peptide hormone receptor binding
GO:0051428
637
Corticotropin-releasing hormone receptor 1 binding
GO:0051430
11
Corticotropin-releasing hormone receptor 2 binding
GO:0051431
2
BH3 domain binding
GO:0051434
13
BH4 domain binding
GO:0051435
5
NFAT protein binding
GO:0051525
857
Iron-sulfur cluster binding
GO:0051536
2400
2 iron, 2 sulfur cluster binding
GO:0051537
2764
4 iron, 4 sulfur cluster binding
GO:0051539
3171
5'-deoxyribose-5-phosphate lyase activity
GO:0051575
744
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051717
5
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0051718
2
Protein phosphatase 2A binding
GO:0051721
432
NAD transporter activity
GO:0051724
2
Polynucleotide 5'-hydroxyl-kinase activity
GO:0051731
2308
Polydeoxyribonucleotide kinase activity
GO:0051733
2
ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
GO:0051736
2
Cytosine C-5 DNA demethylase activity
GO:0051747
3
Misfolded protein binding
GO:0051787
464
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0051800
5
Glycolipid binding
GO:0051861
17
Histone demethylase activity (H3-K36 specific)
GO:0051864
31
Hsp90 protein binding
GO:0051879
2291
G-quadruplex DNA binding
GO:0051880
215
Double-stranded DNA specific 5'-3' exodeoxyribonuclease activity
GO:0051908
3
Peroxiredoxin activity
GO:0051920
3
Dynein light intermediate chain binding
GO:0051959
6
Squalene synthase activity
GO:0051996
10
Sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
GO:0052591
6
Tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052593
5
Aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052594
5
Aliphatic-amine oxidase activity
GO:0052595
5
Phenethylamine:oxygen oxidoreductase (deaminating) activity
GO:0052596
5
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
GO:0052629
288
Lysophosphatidic acid phosphatase activity
GO:0052642
283
NADP-retinol dehydrogenase activity
GO:0052650
1068
L-leucine transaminase activity
GO:0052654
13
L-valine transaminase activity
GO:0052655
13
L-isoleucine transaminase activity
GO:0052656
13
Inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052658
954
Carboxylic ester hydrolase activity
GO:0052689
769
Inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052725
664
Inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052726
664
Phosphocholine phosphatase activity
GO:0052731
2
Phosphoethanolamine phosphatase activity
GO:0052732
2
(R)-limonene 6-monooxygenase activity
GO:0052741
5
Inositol phosphate phosphatase activity
GO:0052745
6
Exo-alpha-(2->3)-sialidase activity
GO:0052794
3
Exo-alpha-(2->6)-sialidase activity
GO:0052795
3
Exo-alpha-(2->8)-sialidase activity
GO:0052796
3
Beta-galactoside alpha-2,3-sialyltransferase activity
GO:0052798
539
Medium-chain-aldehyde dehydrogenase activity
GO:0052814
292
Medium-chain acyl-CoA hydrolase activity
GO:0052815
3
Long-chain acyl-CoA hydrolase activity
GO:0052816
3
Very long chain acyl-CoA hydrolase activity
GO:0052817
3
Inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
GO:0052825
664
Inositol hexakisphosphate 2-phosphatase activity
GO:0052826
4
Inositol-1,3,4-trisphosphate 1-phosphatase activity
GO:0052829
2
Inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
GO:0052830
664
Inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
GO:0052831
664
Inositol monophosphate 3-phosphatase activity
GO:0052832
969
Inositol monophosphate 4-phosphatase activity
GO:0052833
969
Inositol monophosphate phosphatase activity
GO:0052834
355
Inositol-3,4,6-trisphosphate 1-kinase activity
GO:0052835
664
Inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052840
52
Inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052843
52
Inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052844
52
Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052845
52
Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052846
52
Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052847
52
Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052848
52
Ferric-chelate reductase (NADPH) activity
GO:0052851
1207
Very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052852
3
Long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052853
3
Medium-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052854
3
Phosphatidylinositol phosphate phosphatase activity
GO:0052866
273
Arachidonic acid omega-hydroxylase activity
GO:0052869
3
Alpha-tocopherol omega-hydroxylase activity
GO:0052871
45
Tocotrienol omega-hydroxylase activity
GO:0052872
2
All-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
GO:0052884
5
All-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
GO:0052885
5
N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052899
1
Spermine:oxygen oxidoreductase (spermidine-forming) activity
GO:0052901
1
Spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
GO:0052902
1
N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052903
1
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052904
1
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity
GO:0052917
4
Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
GO:0052918
745
Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
GO:0052926
745
D-glucose transmembrane transporter activity
GO:0055056
646
Gap junction hemi-channel activity
GO:0055077
7
Adiponectin binding
GO:0055100
10
Lipase inhibitor activity
GO:0055102
7
Ligase regulator activity
GO:0055103
6
Ubiquitin-protein ligase inhibitor activity
GO:0055105
1
Ubiquitin-protein ligase regulator activity
GO:0055106
8
Minus-end directed microfilament motor activity
GO:0060001
735
Plus-end directed microfilament motor activity
GO:0060002
962
Large conductance calcium-activated potassium channel activity
GO:0060072
22
Binding, bridging
GO:0060090
4
Brain-derived neurotrophic factor-activated receptor activity
GO:0060175
22
Phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0060228
5
Lipase activator activity
GO:0060229
1
Lipoprotein lipase activator activity
GO:0060230
3
Peptidyl-dipeptidase inhibitor activity
GO:0060422
4
Phospholipase D inhibitor activity
GO:0060961
6
Endopeptidase activator activity
GO:0061133
6
NA
GO:0061507
2
NA
GO:0061547
4
NA
GO:0061578
1890
NA
GO:0061597
3
NA
GO:0061598
3
NA
GO:0061599
3
NA
GO:0061609
4
NA
GO:0061627
999
NA
GO:0061628
11
NA
GO:0061629
1
NA
GO:0061630
3568
NA
GO:0061631
1822
NA
GO:0061649
394
Aspartic-type peptidase activity
GO:0070001
4
Glutamic-type peptidase activity
GO:0070002
4
Metalloaminopeptidase activity
GO:0070006
4
Serine-type exopeptidase activity
GO:0070008
523
Serine-type aminopeptidase activity
GO:0070009
7
Oligopeptidase activity
GO:0070012
2
Armadillo repeat domain binding
GO:0070016
71
Nitric oxide binding
GO:0070026
2
Fibrinogen binding
GO:0070051
14
Collagen V binding
GO:0070052
13
Thrombospondin receptor activity
GO:0070053
663
Fructose binding
GO:0070061
11
RNA polymerase binding
GO:0070063
95
Proline-rich region binding
GO:0070064
1505
Titin Z domain binding
GO:0070080
2
Chromo shadow domain binding
GO:0070087
645
Fructose-6-phosphate binding
GO:0070095
2
Delta-catenin binding
GO:0070097
70
Ciliary neurotrophic factor binding
GO:0070119
1356
Transforming growth factor beta receptor activity, type III
GO:0070123
8
DNA polymerase binding
GO:0070182
1478
Phosphatidylinositol-4-phosphate binding
GO:0070273
2595
NAPE-specific phospholipase D activity
GO:0070290
161
Phosphatidic acid binding
GO:0070300
24
Inward rectifier potassium channel inhibitor activity
GO:0070320
7
Thyroid hormone binding
GO:0070324
17
Lipoprotein particle receptor binding
GO:0070325
17
Very-low-density lipoprotein particle receptor binding
GO:0070326
2558
Aromatase activity
GO:0070330
1510
Aspartate binding
GO:0070335
6
Mitochondrial light strand promoter sense binding
GO:0070363
241
NADP+ binding
GO:0070401
1
NADPH binding
GO:0070402
14
NAD+ binding
GO:0070403
940
NADH binding
GO:0070404
6
Co-SMAD binding
GO:0070410
1278
I-SMAD binding
GO:0070411
1131
R-SMAD binding
GO:0070412
1321
Repressing transcription factor binding
GO:0070491
2186
Oligosaccharide binding
GO:0070492
201
Death domain binding
GO:0070513
121
K63-linked polyubiquitin binding
GO:0070530
1667
Oleic acid binding
GO:0070538
12
Linoleic acid binding
GO:0070539
693
Uridylyltransferase activity
GO:0070569
414
Vitamin D 24-hydroxylase activity
GO:0070576
375
Histone acetyl-lysine binding
GO:0070577
933
Methylcytosine dioxygenase activity
GO:0070579
42
Histone methyltransferase activity (H3-R2 specific)
GO:0070611
2
Histone methyltransferase activity (H2A-R3 specific)
GO:0070612
2
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
GO:0070626
2
Proteasome binding
GO:0070628
531
Vitamin D response element binding
GO:0070644
424
High-density lipoprotein particle receptor binding
GO:0070653
2
Inositol 1,4,5 trisphosphate binding
GO:0070679
544
Type I activin receptor binding
GO:0070698
3
Type II activin receptor binding
GO:0070699
7
BMP receptor binding
GO:0070700
1136
Leucine binding
GO:0070728
636
Protein-glycine ligase activity
GO:0070735
176
Protein-glycine ligase activity, initiating
GO:0070736
172
C2H2 zinc finger domain binding
GO:0070742
811
Peptidyl-lysine 5-dioxygenase activity
GO:0070815
748
Chromium ion transmembrane transporter activity
GO:0070835
591
Dynein complex binding
GO:0070840
15
Growth factor receptor binding
GO:0070851
19
Myosin VI binding
GO:0070853
405
Myosin VI light chain binding
GO:0070856
7
E-box binding
GO:0070888
2266
Sodium-dependent L-ascorbate transmembrane transporter activity
GO:0070890
24
Lipoteichoic acid binding
GO:0070891
1
Lipoteichoic acid receptor activity
GO:0070892
659
Serine binding
GO:0070905
9
FHA domain binding
GO:0070975
8
TIR domain binding
GO:0070976
2
SnRNP binding
GO:0070990
1
Medium-chain-acyl-CoA dehydrogenase activity
GO:0070991
1
Type 1 melanocortin receptor binding
GO:0070996
5
RNA trimethylguanosine synthase activity
GO:0071164
103
Histone pre-mRNA stem-loop binding
GO:0071207
386
Histone pre-mRNA DCP binding
GO:0071208
925
U7 snRNA binding
GO:0071209
1
Connexin binding
GO:0071253
837
Ankyrin repeat binding
GO:0071532
32
RING-like zinc finger domain binding
GO:0071535
10
Histone demethylase activity (H3-K27 specific)
GO:0071558
564
UFM1 conjugating enzyme activity
GO:0071568
7
Lipopeptide binding
GO:0071723
696
Chemokine (C-C motif) ligand 5 binding
GO:0071791
3
Lipoprotein particle binding
GO:0071813
677
N-box binding
GO:0071820
3
HMG box domain binding
GO:0071837
420
Protein phosphatase type 1 activator activity
GO:0071862
1878
Vitamin D receptor activator activity
GO:0071884
7
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
GO:0071886
103
14-3-3 protein binding
GO:0071889
886
Arp2/3 complex binding
GO:0071933
1073
Coreceptor activity involved in Wnt receptor signaling pathway
GO:0071936
10
FAD binding
GO:0071949
3020
WD40-repeat domain binding
GO:0071987
529
Volume-sensitive chloride channel activity
GO:0072320
275
Modified amino acid binding
GO:0072341
463
NAADP-sensitive calcium-release channel activity
GO:0072345
47
Peroxynitrite reductase activity
GO:0072541
1
Tyrosine binding
GO:0072545
478
Phosphatidylinositol-3,5-bisphosphate binding
GO:0080025
2549
Phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
GO:0080101
1
AMP transmembrane transporter activity
GO:0080122
2
L-phenylalanine:2-oxoglutarate aminotransferase activity
GO:0080130
751
Fatty acid alpha-hydroxylase activity
GO:0080132
4
L-cysteine desulfhydrase activity
GO:0080146
301
Voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential
GO:0086006
1102
Voltage-gated calcium channel activity involved in regulation of cardiac muscle cell action potential
GO:0086007
9
Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086008
22
Calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
GO:0086039
40
Voltage-gated calcium channel activity involved in regulation of SA node cardiac muscle cell action potential
GO:0086059
9
Voltage-gated sodium channel activity involved in regulation of Purkinje myocyte action potential
GO:0086062
4
Voltage-gated sodium channel activity involved in regulation of SA node cardiac muscle cell action potential
GO:0086063
14
Gap junction channel activity involved in cardiac conduction electrical coupling
GO:0086075
2
Gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
GO:0086077
2
Protein binding involved in heterotypic cell-cell adhesion
GO:0086080
158
Voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization
GO:0086089
6
Nicotinate transporter activity
GO:0090416
3
NA
GO:0090450
10
NA
GO:0090541
124
Ceramide binding
GO:0097001
14
L27 domain binding
GO:0097016
702
Ubiquitin-protein ligase activator activity
GO:0097027
7
Supercoiled DNA binding
GO:0097100
3
Hedgehog family protein binding
GO:0097108
23
Neuroligin family protein binding
GO:0097109
1067
Scaffold protein binding
GO:0097110
2625
Cysteine-type endopeptidase activity involved in apoptotic process
GO:0097153
1319
Pre-mRNA intronic binding
GO:0097157
20
Organic cyclic compound binding
GO:0097159
5
DH domain binding
GO:0097161
6
Mitochondrial ribosome binding
GO:0097177
3
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097199
1547
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0097200
1
Eoxin A4 synthase activity
GO:0097260
191
NA
GO:0097371
1443
NA
GO:0097372
1064
NA
GO:0097383
10
NA
GO:0097493
64
NA
GO:0097573
3
NA
GO:0097602
1593
NA
GO:0098519
160
NA
GO:0098531
24
NA
GO:0098599
32
NA
GO:0098639
748
NA
GO:0098640
1
NA
GO:1901611
2
NA
GO:1901612
661
NA
GO:1901640
10
NA
GO:1901641
10
NA
GO:1901981
24
NA
GO:1902098
415
NA
GO:1902121
415
NA
GO:1902122
126
NA
GO:1902282
20
NA
GO:1903135
1
NA
GO:1903136
1
NA
GO:1990050
729
NA
GO:1990081
1
NA
GO:1990136
1
NA
GO:1990175
2
NA
GO:1990188
1
NA
GO:1990226
16
NA
GO:1990239
680
NA
GO:1990247
8
NA
GO:1990254
10
NA
GO:1990272
1
NA
GO:1990380
1883
NA
GO:1990381
805
NA
GO:1990422
1
NA
GO:1990430
480
NA
GO:1990444
797
NA
GO:1990450
2
NA
GO:1990459
622
NA
GO:1990460
622
Mannan binding
GO:2001065
5
Glycogen binding
GO:2001069
5
Starch binding
GO:2001070
2